نتایج جستجو برای: cetp

تعداد نتایج: 1082  

2008
ANJU SINGH RICHA GAUTAM

Several small scale industries have formed cooperatives and established Common Effluent Treatment Plants (CETP) to treat wastewater in India. The wastewaters are subjected to primary treatment in the industry and thereafter discharged to be further treated at the CETPs. The management and treatment costs are shared by the member industries. The CETP under study is situated in North Western part...

Journal: :Proteins 2013
Dongsheng Lei Xing Zhang Shengbo Jiang Zhaodi Cai Matthew J Rames Lei Zhang Gang Ren Shengli Zhang

Cholesteryl ester transfer protein (CETP) mediates the net transfer of cholesteryl esters (CEs) from atheroprotective high-density lipoproteins (HDLs) to atherogenic low-density lipoproteins (LDLs) or very-low-density lipoproteins (VLDLs). Inhibition of CETP raises HDL cholesterol (good cholesterol) levels and reduces LDL cholesterol (bad cholesterol) levels, making it a promising drug target f...

Journal: :The Journal of clinical investigation 2006
Fumihiko Matsuura Nan Wang Wengen Chen Xian-Cheng Jiang Alan R Tall

Genetic deficiency or inhibition of cholesteryl ester transfer protein (CETP) leads to a marked increase in plasma levels of large HDL-2 particles. However, there is concern that such particles may be dysfunctional in terms of their ability to promote cholesterol efflux from macrophages. Recently, the ATP-binding cassette transporter ABCG1, a macrophage liver X receptor (LXR) target, has been s...

Journal: :Aging cell 2012
Lei Yu Joshua M Shulman Lori Chibnik Sue Leurgans Julie A Schneider Philip L De Jager David A Bennett

The cholesteryl ester transfer protein (CETP) gene plays an essential role in regulating cholesterol homeostasis and is a candidate susceptibility gene for late-onset Alzheimer's disease (AD). Recent finding suggests that the CETP I405V polymorphism (rs5882) is associated with a slower rate of memory decline and a lower risk of incident dementia. Using data from two ongoing epidemiologic clinic...

2014
Caitlin Munger Ammon Perkes Michael Peterson Cameron Schmutz Maegan Leary Mark T. W. Ebbert Perry G. Ridge Maria C. Norton JoAnn T. Tschanz Ronald G. Munger Christopher D. Corcoran John S. K. Kauwe

Cholesterol has been implicated in the pathogenesis of Late-onset Alzheimer's disease (LOAD) and the Cholesteryl Ester Transfer Protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer’s disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated with cognitive function and LOAD risk, but findings vary and most studies have...

Journal: :Neurobiology of aging 2015
Caitlin Lythgoe Ammon Perkes Michael Peterson Cameron Schmutz Maegan Leary Mark T W Ebbert Perry G Ridge Maria C Norton JoAnn T Tschanz Ronald G Munger Christopher D Corcoran John S K Kauwe

Cholesterol has been implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD) and the cholesteryl ester transfer protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer's disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated with cognitive function and LOAD risk, but findings vary and most studies have...

Journal: :Thrombosis and haemostasis 2007
Hiroshi Deguchi José A Fernández John H Griffin

Dyslipoproteinemia involving low levels of high density lipoprotein (HDL) is linked to venous thrombosis in young male adults and to recurrence of venous thrombosis in patients who have experienced a previous unprovoked venous thrombosis episode. Plasma cholesteryl ester transfer protein (CETP) modulates HDL metabolism and some lipoproteins can affect blood coagulation reactions with either pro...

Journal: :Journal of lipid research 2006
David Masson Jean-Paul Pais de Barros Zoulika Zak Thomas Gautier Naig Le Guern Mahfoud Assem Jeffrey W Chisholm James R Paterniti Laurent Lagrost

Plasma cholesteryl ester transfer protein (CETP) has a profound effect on neutral lipid transfers between HDLs and apolipoprotein B (apoB)-containing lipoproteins when it is expressed in combination with human apoA-I in HuAI/CETP transgenic (Tg) rodents. In the present study, human apoA-I-mediated lipoprotein changes in HuAI/CETPTg rats are characterized by 3- to 5-fold increments in the apoB-c...

Journal: :The Journal of clinical investigation 1991
C J Mann F T Yen A M Grant B E Bihain

Plasma net cholesteryl ester (CE) transfer and optimum cholesteryl ester transfer protein (CETP) activity were determined in primary hypertriglyceridemic (n = 11) and normolipidemic (n = 15) individuals. The hypertriglyceridemic group demonstrated threefold greater net CE transfer leading to enhanced accumulation of CE in VLDL. This increased net transfer was not accompanied by a change in CETP...

Journal: :Journal of lipid research 2011
Yanan Wang Jimmy F P Berbée Erik S Stroes Johannes W A Smit Louis M Havekes Johannes A Romijn Patrick C N Rensen

Human data suggest that reconstituted HDL (rHDL) infusion can induce atherosclerosis regression. Studies in mice indicated that rHDL infusion adversely affects VLDL levels, but this effect is less apparent in humans. This discrepancy may be explained by the fact that humans, in contrast to mice, express cholesteryl ester transfer protein (CETP). The aim of this study was to investigate the role...

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