AIMS To examine human papillomavirus (HPV) positive and negative squamous cell carcinomas of the cervix for structural alterations in exon 1 c-myc; and to investigate the expression pattern of p62, the protein product of c-myc. MATERIAL Archival paraffin wax embedded tissues of cervical squamous cell carcinomas, stage I and II, retrieved from the files of the department of pathology, Universi...

Introduction: Sarcoma of the cervix is uncommon and its prevalence is about 1% of malignancies of the cervix. One type of sarcoma is leiomyosarcoma and the location of this tumor in cervix is very rare. Although uterine sarcoma can involve the cervix and lead to misdiagnosis of cervical leiomyosarcoma, the location of the bulk of the tumor in uterine cervix (not isthmus) for diagnosis of cervic...

Background: Cancer cervix is the most common cancer in women of the developing countries where screening facilities are inadequate. Cancer cervix is a preventable cancer due to its long pre invasive stage and availability of screening methods. Colposcopy is an in situ clinical examination of cervix with magnification and illumination. It is a clinical method that complements the laboratory meth...

Standard radiation therapy for patients undergoing primary chemosensitized radiation for carcinomas of the cervix usually consists of external beam radiation followed by an intracavitary brachytherapy boost. On occasion, the brachytherapy boost cannot be performed due to unfavorable anatomy or because of coexisting medical conditions. We examined the safety and efficacy of using CyberKnife ster...

The overall five-year survival of cervical cancer is only 40% worldwide despite the development of effective screening modalities. Paramount to this issue is access to appropriate medical care which remains limited to high-risk populations throughout the world. While surgery and radiation remain the mainstays of current treatment, new therapies based on the association of cervical cancer with t...

A decline in serum progesterone or antagonism of progesterone receptor function results in preterm labor and birth. Whether characteristics of premature remodeling of the cervix after antiprogestins or ovariectomy are similar to that at term was the focus of the present study. Groups of pregnant rats were treated with vehicle, a progesterone receptor antagonist (onapristone or mifepristone), or...

Whether someone?s in a strictly monogamous relationship or exploring their sexuality with multiple partners, the most common cause of cervical cancer is human papillomavirus (HPV). This virus, which has many strains, has been linked to a number of cancers, including cervical cancer. The reason the risk of getting HPV increases along with the number of sexual partners a person has is as follows:...

Small cell carcinoma of the uterine cervix is rare. It is estimated that 10% of patients with small-cell lung cancer have syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and hyponatremia has been reported to be significantly associated with a poor prognosis. A proportion of small cell carcinoma of the uterine cervix exhibit neuroendocrine characteristics as revealed by immun...