background & objectives: tumor diathesis (td) is defined as granular proteinaceous precipitates on slide surface of cytologic smears. it is found in the background of smears of invasive carcinoma but not in all cases. the aim of present study was to determine the prevalence of td in cervicovaginal smears from patients with uterine cervix carcinoma. methods: cytological smears and histologi...

Worldwide, human immunodeficiency virus (HIV) is transmitted predominantly by heterosexual contact. Here, we investigate for the first time, by examining mononuclear cells obtained from cervicovaginal tissue, the mechanisms whereby HIV type 1 (HIV-1) directly targets cells from the human genital tract. In contrast to earlier findings in mucosal models such as human skin, we demonstrate that the...

HIV resides within anatomical 'sanctuary sites', where local drug exposure and viral dynamics may differ significantly from the systemic compartment. Suboptimal antiretroviral concentrations in the genital tract may result in compartmentalized viral replication, selection of resistant mutations and possible re-entry of wild-type/resistant virus into the systemic circulation. Therefore, achievin...