نتایج جستجو برای: ceramide

تعداد نتایج: 5724  

Journal: :The Journal of biological chemistry 2005
Yosuke Osawa Hiroshi Uchinami Jacek Bielawski Robert F Schwabe Yusuf A Hannun David A Brenner

Tumor necrosis factor (TNF)-alpha signals cell death and simultaneously induces the generation of ceramide, which is metabolized to sphingosine and sphingosine 1-phosphate (S1P) by ceramidase (CDase) and sphingosine kinase. Because the dynamic balance between the intracellular levels of ceramide and S1P (the "ceramide/S1P rheostat") may determine cell survival, we investigated these sphingolipi...

Journal: :Molecular cancer therapeutics 2002
Hongtao Wang Armando E Giuliano Myles C Cabot

SDZ PSC 833 (PSC 833), a P-glycoprotein-targeted multidrug resistance modulator, sensitizes cancer cells to chemotherapy. Here we show that PSC 833 also potentiates the formation of ceramide. Because ceramide is a second messenger in chemotherapy-induced apoptosis, knowledge of the lipid pathways influenced by PSC 833 is of relevance. In intact MDA-MB 468 breast cancer cells, ceramide generatio...

Journal: :The Journal of biological chemistry 1982
S L Sutrina W W Chen

Two isoenzymes of ceramidase, including lysosomal acid ceramidase and nonlysosomal alkaline ceramidase, catalyze the degradation of ceramide in cultured human skin fibroblasts. A genetically determined disorder of sphingolipid metabolism (Farber's-disease) is characterized by the deficiency of acid ceramidase and by the pathological accumulation of ceramide. In this report, we take advantage of...

Journal: :Urology 2003
Hongtao Wang Anthony G Charles Aaron J Frankel Myles C Cabot

OBJECTIVES To investigate the feasibility of targeting ceramide metabolism to enhance chemotherapy cytotoxicity in prostate cancer. Discovering new targets for cancer treatment is an important endeavor, especially in prostate malignancies, which often revert to hormone- and chemotherapy-refractory disease states. METHODS Ceramide metabolism was measured in human prostate cancer cell lines usi...

Journal: :The Journal of biological chemistry 2003
Scott R Witting J Nicholas Maiorano W Sean Davidson

It is widely accepted that functional ATP-binding cassette transporter A1 (ABCA1) is critical for the formation of nascent high density lipoprotein particles. However, the cholesterol pool(s) and the cellular signaling processes utilized by the ABCA1-mediated pathway remain unclear. Sphingomyelin maintains a preferential interaction with cholesterol in membranes, and its catabolites, especially...

2006
Mark Garzotto Margaret White-Jones Youwei Jiang Wen-Chieh Liao Adriana Haimovitz-Friedman Zvi Fuks Richard Kolesnick

Protein kinase C i I'M i activation is often antiapoptotic, although in a few cell types PKC initiates apoptosis by an unknown mechanism. Recent investigations showed that activation of PKCa by 12-0-tetradecanoylphorbol 13-acetate (TPA) induced apoptosis in LNCaP prostate cancer cells. The present studies examine the mechanism of this effect and show that (/<• novo ceramide generation through...

Journal: :Blood 2005
Takeshi Yabu Hidekazu Tomimoto Yoshimitsu Taguchi Shohei Yamaoka Yasuyuki Igarashi Toshiro Okazaki

Thalidomide, which is clinically recognized as an efficient therapeutic agent for multiple myeloma, has been thought to exert antiangiogenic action through an unknown mechanism. We here show a novel mechanism of thalidomide-induced antiangiogenesis in zebrafish embryos. Thalidomide induces the defect of major blood vessels, which is demonstrated by their morphologic loss and confirmed by the de...

2009
Esther Marza Karina T. Simonsen Nils J. Færgeman Giovanni M. Lesa

Glycosphingolipids (GSLs) are complex glycolipids derived from ceramide. They consist of a ceramide lipid moiety (a fatty acid chain linked to a sphingoid base) embedded in the cell membrane, which is attached to a wide variety of oligosaccharide structures that extend from the non-cytosolic leaflet of the lipid bilayer (Degroote et al., 2004; Lahiri and Futerman, 2007). The ceramide is made in...

Journal: :Circulation 2002
Huige Li Peter Junk Andrea Huwiler Christian Burkhardt Thomas Wallerath Josef Pfeilschifter Ulrich Förstermann

BACKGROUND Generation of the second-messenger molecule ceramide by stimulated sphingomyelinase activity has been implicated in the inflammatory processes contributing to the pathogenesis of atherosclerosis. However, reports of stimulatory effects of ceramide on endothelial NO production in animal models suggest antiatherosclerotic effects of the molecule. Therefore, we investigated long-term ef...

Journal: :Molecular pharmacology 2003
Belen Ramos Jill M Lahti Enrique Claro Suzanne Jackowski

The mechanism of cell death triggered by C2-ceramide was investigated using the NB16 neuroblastoma cell line. Treatment of NB16 cells with 20 microM C2-ceramide for 20 h resulted in approximately 75% loss of cell viability, but only 25% of cells were scored as apoptotic based on terminal deoxynucleotidyl transferase nick-end labeling. Ultrastructural analysis revealed early development of necro...

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