With the growth of the developing embryonic brain, increasing requirements for oxygen and metabolic substrates demand a more comprehensive and complex vascular system. Covering the entire neuraxis is a primitive network of mesenchymal cells known as the meninx primitiva. The meninx follows the folds that appear during development of the brain, filling the interhemispheric fissure that forms bet...

Meningitis is the most serious manifestation of extrapulmonary tuberculosis. Being a paucibacillary disease, no single diagnostic test is sensitive and specific. Despite recent advances in diagnostic methods and readily available effective chemotherapy, more than 50% of the patients either die or are left with major neurological deficits due to delay in the diagnosis. HIV coinfection is associa...

Primary central nervous system lymphoma (PCNSL) is characterized by extranodal malignant lymphomas arising in the brain, spinal cord, CSF, and eyes in the absence of lymphoma outside the nervous system at the time of diagnosis (Deckert & Paulus, 2007). By definition, this excludes CNS involvement of systemic lymphomas and angiotropic lymphomas (Schlegel et al., 2000). The incidence of PCNSL in ...

This chapter provides an overview of the major stages of prenatal central nervous system (CNS) development. CNS development plays the central role in the primary argument of this book. That argument is that the prenatal CNS is particularly vulnerable to environmental perturbations because it is rapidly developing during that time period. Further, we argue that many of the learning and behaviora...

This chapter provides an overview of the major stages of prenatal central nervous system (CNS) development. CNS development plays the central role in the primary argument of this book. That argument is that the prenatal CNS is particularly vulnerable to environmental perturbations because it is rapidly developing during that time period. Further, we argue that many of the learning and behaviora...