Macropinocytosis is a ubiquitous cellular uptake mechanism of peptide-based intracellular delivery. This entry pathway shows promise as route for the biomacromolecules and nanoparticles. In this work, we obtained 8-residue analogue P4A bearing higher macropinocytosis induction ability. contains vital cysteine residues in its sequence, which immediately reacts with cystine culture medium to conv...

Engineered polymers have been utilized for developing advanced drug delivery systems. The development of such polymers has caused advances in polymer chemistry, which, in turn, has resulted in smart polymers that can respond to changes in environmental condition such as temperature, pH, and biomolecules. The responses vary widely from swelling/deswelling to degradation. Drug-polymer conjugates ...

Transdermal systems are non-invasive, convenient, and inexpensive and can be self-administered. They can provide sustained plasma concentration profile for long periods of time. The systems can greatly improve patient compliance through avoidance of first-past metabolism, improved bioavailability, reduction of systemic side effects and dosing schedule. In the past three decades, transdermal dru...

The advancement of next-generation nanocarriers as drug delivery platforms will require the incorporation of these useful properties, through which adverse side effects of chemotherapy drugs can be avoided and overall treatment and diagnosis improved. As such, a variety of nanoparticle-based delivery systems have already been widely investigated and provided interesting avenues of research for ...

objective: this study focused on the factors affecting the institutional delivery and delivery assisted by health professionals in urban slums. materials and methods: a semi-structured questionnaire was developed to collect information from women aged 15-49 who had at least one birth. totally 540 eligible women were interviewed. results: the results showed that around 20% of women delivered at ...

Despite the discovery of many potential antigens for subunit vaccines, universal protection is often lacking due to the limitations of conventional delivery methods. Subunit vaccines primarily induce antibody-mediated humoral responses, whereas potent antigen-specific cellular responses are required for prevention against some pathogenic infections. Nanoparticles have been utilised in nanomedic...

BACKGROUND Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as cell accumulation and active intra- and inter-cellular motion through cell-to-cell contacts and projections to distant cells. On the basis of these properties dynein-binding pe...

A new method for facilitating the delivery, uptake and intracellular localisation of thermally activated delayed fluorescence (TADF) complexes was developed. First, confinement TADF in liposomes demonstrated, which were subsequently used as delivery vehicle cellular uptake. Confocal microscopy showed localise cytoplasm HepG2 cells. The procedures developed this work included removal molecular o...