scorpion venom toxicity is of major concern due to its influence on human activities and public health. we investigated the in-vitro process of cell death caused by two iranian scorpions odontobuthus doriae and bothutus salceyi venom on human cell lines. the aim of this study was to provide further information about triggering cell death and suggestion of methods for the elimination of unwanted...

• Werner syndrome is an adult-onset of accelerated aging predisposing to solid cancer and hematological malignancies. Chemotherapy stem cell transplantation was successful in a patient with AML. Despite the poor risk profile, remains remission 5 years after toxicity acceptable.

Chronic toxicity test was conducted for 28 days with post larval stages of Penaeus indicus to arsenic for studying the changes associated with growth pattern, specifying the length, weight and condition factor. Arsenic exposures produced significant (P < 0.05) effect in terms of length, weight and deteriorated the condition factor of the test animal. Differentiation in relation between the cond...

In 2007, the U.S. National Academy of Sciences released a report, Toxicity Testing in the 21st Century: A Vision and a Strategy, that envisions a not-so-distant future in which virtually all routine toxicity testing would be conducted in human cells or cell lines in vitro by evaluating cellular responses in a suite of toxicity pathway assays using high-throughput tests, that could be implemente...

Background: Toxicity assessment is done by comparing HDR brachytherapy with ICRU point doses. D2cc doses of OAR in slightly more than Objectives:The primary objective volumetric dose and toxicity comparison between brachytherapy. Materials Methods: It a prospective comparative study. The total number patients enrolled the study 20. After obtaining informed consent, then were All diagnosed H.P.E...

Prolonged exposure to the flame retardants found in many household products and building materials is associated with adverse developmental, reproductive, and carcinogenic consequences. While these compounds have been studied in numerous epidemiological and animal models, less is known about the effects of flame retardant exposure on cell function. This study evaluated the toxicity of the commo...

introduction: there have been many studies in recent years on the role of nitric oxide (no) in acute renal failure. in this study, the effects of inhibition or interoduction of no synthase on renal toxicity of gentamicin were investegated. materials & methods: isolated kidneys of male rats were perfused with tyrode buffer (t) as the control group, t+l-argrinine as group 2, t+l-name as group 3, ...

Concerns, legislation and research needs have precipitated developments such as the mode of action concept, the Tox21 strategy, the concept of pathways of toxicity and the adverse outcome pathway framework. New technologies and paradigms are currently transforming these concepts into applicable animal-free toxicity testing systems. The adverse outcome pathway framework provides a structure for ...

Algal toxicity tests based on growth inhibition over 72 h have been extensively used to assess the toxicity of contaminants in natural waters. However, these laboratory tests use high cell densities compared to those found in aquatic systems in order to obtain a measurable algal response. The high cell densities and test duration can result in changes in chemical speciation, bioavailability, an...