objective: assessments of cell reactions such as motility, orientation and activation to the topography of the substratum will assist with the fabrication of a proper implantable scaffold for future tissue engineering applications.the current challenge is to analyze the orientation effect of elecrospun nanofibers of poly (ε-caprolactone) (pcl) on viability and proliferation of mouse embryonic s...

Electrostatic endothelial cell seeding has evolved as an exceptional technique to improve the efficiency of cell seeding in terms of frequency of attached cells and the amount of cell adhesion for the treatment of vascular diseases. In the recent times, both untreated and superhydrophilic thin film nitinol (TFN) have exhibited strong prospects as substrates for creation of small-diameter endova...

We compared the modeled energy spectral density of very low frequency (VLF) radio emissions from terrestrial gamma ray flashes (TGFs) with the energy spectral density of VLF radio sferics recorded by Duke VLF receiver simultaneously with those TGFs. In total, six events with world wide lightning location network (WWLLN) defined locations were analyzed to exhibit a good fit between the modeled a...

Transcellular propagation of protein aggregates, or proteopathic seeds, may drive the progression of neurodegenerative diseases in a prion-like manner. In tauopathies such as Alzheimer's disease, this model predicts that tau seeds propagate pathology through the brain via cell-cell transfer in neural networks. The critical role of tau seeding activity is untested, however. It is unknown whether...

Introduction. A critical step for the in vitro engineering of a threedimensional tissue is to initially achieve a uniform distribution of cells seeded throughout the entire scaffold. Furthermore, if autologous cells are to be used in a clinical application, cells isolated from a small biopsy must be utilized with maximum efficiency. To overcome limitations associated with the most commonly empl...

Biomaterial scaffolds are components of cell-laden artificial tissues and transplantable biosensors. Some of the most promising new synthetic biomaterial scaffolds are composed of self-assembling peptides that can be modified to contain biologically active motifs. Peptide-based biomaterials can be fabricated to form two- and three-dimensional structures. Recent studies show that biomaterial pro...

introduction perforation of maxillary sinus mucous membrane is of the most prevalent complication during open sinus lift surgery. moreover, such complication can usually be managed by an absorbable membrane. as far as absorbable membranes are concerned, decellularized maxillary sinus mucous membranes, which is an extracellular matrix, can be used as a biologic scaffold and insulating membrane i...

Tumor cells that disseminate from the primary tumor and survive the vascular system can eventually extravasate across the endothelium to metastasize at a secondary site. In this study, we developed a microfluidic system to mimic tumor cell extravasation where cancer cells can transmigrate across an endothelial monolayer into a hydrogel that models the extracellular space. The experimental proto...