Oxidative stress is considered a cause or propagator of acute and chronic disorders of the central nervous system. Novel 2, 4-diamino-pyrrolo[2,3-d]pyrimidines are potent inhibitors of iron-dependent lipid peroxidation, are cytoprotective in cell culture models of oxidative injury, and are neuroprotective in brain injury and ischemia models. The selection of lead candidates from this series req...

In this data article, we described the detailed synthetic procedure and the experimental data for the synthesis of a red-fluorescent probe for calcium ions (Ca2+) with improved water solubility. This Ca2+ red-fluorescent probe CaTM-3 AM could be applied to fluorescence imaging of physiological Ca2+ concentration changes in not only live cells, but also brain slices, with high cell-membrane perm...

Affinity membranes have the potential to enhance specific adsorption of toxins, however, they suffer from insufficient hemocompatibility and low therapeutic efficiency during blood detoxification therapy. Herein, we combine an affinity membrane with a bioreactor develop purification cell functions. To fabricate membrane, polyethersulfone (iPES) macroporous support layer was prepared by phase in...

Objective(s) Physiological changes in the body may be utilized as potential triggers for controlled drug delivery. Based on these mechanisms, stimulus-responsive drug delivery has been developed. Materials and Methods In this study, a kind of poly (N-isopropylacrylamide-acrylamide) membrane was prepared by radical copolymerization. Changes in swelling ratios and diameters of the membrane wer...

objective (s): transdermal preparations for testosterone are becoming popular because of their unique advantages such as avoidance of first-pass effect, convenience, improved bioavailability, and reduction of systemic side effects. a novel testosterone transdermal delivery system (tdds) was developed using a palm oil base called hamintm (a commercial product) and tested using in vitro and in vi...

Membrane permeability to ions and small molecules is believed to be a critical step in the pathology of Alzheimer's disease (AD). Interactions of oligomers formed by amyloid-β (Aβ) peptides with the plasma cell membrane are believed to play a fundamental role in the processes leading to membrane permeability. Among the family of Aβs, pyroglutamate (pE)-modified Aβ peptides constitute the most a...

Salinity stress is known to modify the plasma membrane lipid and protein composition of plant cells. In this work, we determined the effects of salt stress on the lipid composition of broccoli root plasma membrane vesicles and investigated how these changes could affect water transport via aquaporins. Brassica oleracea L. var. Italica plants treated with different levels of NaCl (0, 40 or 80mM)...

sulfonated poly (ether ether ketone) (speek) with a low degree of sulfonation (ds = 40%) was prepared for proton exchange membrane fuel cells (pemfc). poly (ether ether ketone) (peek) was sulfonated in concentrated h2so4 under n2 atmosphere and characterized by the hydrogen nuclear magnetic resonance (h-nmr) technique. after preparation of the speek polymer, the obtained polymer was dissolved i...

Polyethersulfone (PES) based nanocomposite nanofiltration membrane was prepared by immersion precipitation method and casting solution technique using  poly (acrylic acid) grafted-iron oxide nanoparticles (Fe3O4) as hydrophilic filler additives. For this purpose, iron oxide nanoparticles were modified by in situ polymerization of acrylic acid in aqueous solution by potassium persulfate as initi...

2208 CUNICAL CHEMISTRY, Vol. 39, No. 10, 1993 An altered membrane permeability due to a diffuse ischemic process could have caused the increase in the enzyme activities observed. Increased serum CK and CK-MB activities of this magnitude in the presence of hypethermia may indicate a variable susceptibility of individuals to the effects of hypothermia. These findings may be important in the use o...