Serum-based diagnosis offers the prospect of early lung carcinoma detection and of differentiation between benign and malignant nodules identified by CT. One major challenge toward a future blood-based diagnostic consists in showing that seroreactivity patterns allow for discriminating lung cancer patients not only from normal controls but also from patients with non-tumor lung pathologies. We ...

Introduction Lung lesions include a large variety of benign and malignant conditions. Lung carcinoma is the most common carcinoma in the world today, comprising 12.6% of all the cancers and 17.8% of all the [1] cancer deaths. Benign lesions include inflammatory conditions comprising of acute Inflammatory conditions, granulomatous inflammation, specific infections ( Aspergillus, Phycomycetes, Fu...

EPHA7 is a member of the EPHA family of receptor kinases, among which several members are known to be involved in human lung carcinogenesis. We report here a novel spliced variant, the so-called secreted form of EPHA7, recently reported in malignant lymphoma, in human lung cancer cell lines and primary lung cancer. In contrast to the EPHA7 down-regulation in colorectal cancer by promoter hyperm...

Plasminogen activator inhibitor-1 (PAI-1), the major circulating inhibitor of urokinase [urokinase-type plasminogen activator (uPA)], has been linked to the pathogenesis of lung cancer. PAI-1 belongs to the serpin family of inhibitors and inhibits both free urokinase (uPA) and receptor-bound urokinase (uPA receptor). Although PAI-1 has been related to a poor prognosis in lung carcinoma, mechani...

What is Lung Cancer (Large Cell Carcinoma of the Lung) Lung cancers are tumours arising from cells lining the airways of the respiratory system. One type of lung cancer is known as Large Cell Carcinoma. The cells of this tumour appear large and abnormal under the microscope. Statistics on Lung Cancer (Large Cell Carcinoma of the Lung) Lung cancer is common. One in every 28 Australians will deve...

Large cell neuroendocrine carcinoma (LCNEC) is a poorly differentiated that typically arises in the lung. Because of its rarity and poor prognosis, standardized treatment has not been established yet. A 53-year-old male was initially diagnosed as maxillary sinus squamous (SCC) arising from inverted papilloma (clinical stage T4bN2bM0, IVb), underwent concurrent chemoradiotherapy. After achieving...

Lung cancer is the most common malignancy across world. The new era in lung treatments, especially this past decade, has yielded novel categories of targeted therapy for specific mutations and adjuvant therapy, both which have led to improved survival rates. In present study, we review changes development with a special focus on using tyrosine kinase inhibitors (TKIs) administered non-small-cel...