Myelodysplastic syndromes (MDS) comprise a heterogeneous group of malignant hematopoietic stem cell disorders that are characterized by ineffective blood production and variable risk transformation into acute myeloid leukemia. In recent years, significant progress in MDS biological research has allowed the addition new drugs to few existing therapeutic options. This article presents recommendat...

Acute lymphocytic leukemia (ALL) is one of the frequent malignancies in pediatrics and involves bone marrow and extramedullary sites. Proptosis as extramedullary involvement of leukemia usually present in acute and chronic myeloid leukemia. It is extremely rare for ALL to present initially as proptosis.Here, a-21-month-old boy was presented with proptosis without any associated symptoms except ...

evaluation of the factors associated with treatment process of leukemia and comparison with current related approaches in developed countries can present a good indicator to assess the weak and strong points in healthcare system of our country in leukemia treatment. the objective of this research is general and specific description of the challenges and shortcomings in iranian healthcare system...

Hemophagocytic lymphohistiocytosis (HLH) is a high-fatality disease caused by hereditary or acquired immune dysfunction, and characterized pathological inflammatory response. Primary HLH (pHLH) has genetic defects, secondary (sHLH) variety of underlying diseases. Here, we report the case patient with aggressive natural killer cell leukemia HLH-related gene defects who achieved long-term surviva...

MicroRNAs (miRNAs, miRs) are small endogenous non-coding RNAs that regulate the expression of protein-encoding genes at the post-transcriptional level. Several studies have described the role of miRNAs in T-cell acute lymphoblastic leukemia (T-ALL), including tumor suppressor and oncogenic miRNAs. Down-regulation of miRNA expression is a prominent feature of human malignancy. This down-regulati...

Central nervous system infiltration by acute leukemia is a poor prognosis variable, and conventional cytology the gold standard for its diagnosis; technique highly specific but not sensitive. To improve diagnosis, flow cytometry has been used in different studies, showing greater sensitivity detection of leukemic cells. This study aimed to evaluate presence tumor cells flowcytometry cytology, c...

Пре- и посттрансплантационные факторы, ассоциированные с первичной недостаточностью тяжелой дисфункцией трансплантата после аллогенной трансплантации гемопоэтических стволовых клеток при хроническом миелоидном лейкозеPre- and post-transplantation factors associated with primary graft failure severe poor function after allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia

Myeloid sarcoma of female breast is a rare presentation of acute myeloid leukemia (AML). The tumor mass may precede or occur concurrently with AML, CML, myeloproliferative disorders, and/or myelodysplastic syndromes. Histologically, it looks like a large cell lymphoma and can be misdiagnosed. A case refe...