To understand the growth-promoting and disease-inhibiting activities of plant growth-promoting rhizobacteria (PGPR) strains, the genomes of 12 Bacillus subtilis group strains with PGPR activity were sequenced and analyzed. These B. subtilis strains exhibited high genomic diversity, whereas the genomes of B. amyloliquefaciens strains (a member of the B. subtilis group) are highly conserved. A pa...

The general stress regulon of Bacillus subtilis is controlled by σ(B), a transcription factor that is activated by physical or nutritional stress. In B. subtilis, each of these two stresses is communicated to the primary σ(B) regulators by distinct pathways. Physical stress activation of σ(B) involves a large-molecular-mass (>10(6)-Da) structure (stressosome) formed by one or more homologous pr...

In pursuit of designing novel chemical entities with antitumor and antimicrobial activities, 2-[(5-methyl-1,3-benzoxazol-2-yl)sulfanyl]acetohydrazidederivatives have been synthesized as a scaffold series amine derivatives, these analogs were on reductive amination solvent free condition. All the compounds assessed for antibacterial, antifungal, activities against standard strains. The 3a, 3b 3g...

Pandoraea species have emerged as opportunistic pathogens among cystic fibrosis (CF) and non-CF patients. Pandoraea pulmonicola is the predominant Pandoraea species among Irish CF patients. The objective of this study was to investigate the pathogenicity and potential mechanisms of virulence of Irish P. pulmonicola isolates and strains from other Pandoraea species. Three patients from whom the ...


 In the present investigation, antimicrobial activity of Catharanthus roseus (leaves and stem) was evaluated. The plant material extracted through maceration method results were recorded against different bacterial (Bacillus subtilis Pseudomonas flourescence) fungal (Aspergillus flavus Fusarium culmorum) strains. zones inhibition measured these strains compared with commercially available...

In Guillain-Barré syndrome (GBS), ganglioside mimicry of Campylobacter jejuni lipo-oligosaccharide (LOS) drives the production of cross-reactive Abs to peripheral nerve gangliosides. We determined whether sialic acid residues in C. jejuni LOS modulate dendritic cell (DC) activation and subsequent B cell proliferation as a possible mechanism for the aberrant humoral immune response in GBS. Highl...

Construction of YkoU and YkoV mutant B. subtilis strains. Strains BFS1845 and BFS1846 were constructed using the plasmid pMUTIN4 (S1). PCR-amplified fragments of an internal region of YkoU or YkoV were cloned into the Eco RI–Bam HI sites of pMUTIN4. A 32–base pair (bp) PCR fragment of the YkoU gene, synthesized using the primers SM44 (5 &&**$$77&&$$$7**$&7**$&& DQG 60 CGCGGATCCGACATATCCTCACAGAC...

A positive effect of flaxseed mucilage (FSM) addition (at concentrations 0.1, 0.2, and 0.4%) to MRS milk whey nutrient medium on the survival, auto-aggregation, hydrophobicity, adhesive, antioxidant properties L. bulgaricus, fermentum AG8, plantarum AG9 was shown. It found that AG 8 strain became less sensitive 7% NaCl (the cell survival rate in experiment with 0.4% increased by 10% compared co...

In this research, antagonistic activity of two Bacillus species isolated from digestive tract of marine fish and culture pond of sea cucumber was studied. The inhibitory activity of Bacillus spp. isolates against some common pathogenic bacteria of fish was assessed using the agar diffusion method. The strain of B. subtilis G024 exhibited antimicrobial activity against Vibrio anguillarum, V. har...

BACKGROUND & OBJECTIVES Melioidosis caused by Burkholderia pseudomallei is an emerging disease in India. This study examined the toxin activity of bacteria-free culture filtrate in three different cell lines (cytotoxic assay) and its effect on Caenorhabditis elegans (nematode toxicity assay). Endotoxic activity of the viable bacteria was also studied in C. elegans (co-culture killing assay). ...