the aim of this study was to design orally disintegrating tablets of olanzapine and to complex olanzapine with 2-hydroxypropyl-β- cyclodextrin with special emphasis on disintegration and dissolution studies. phase solubility studies demonstrated the formation of 1:1 molar inclusion complex by kneading method. tablets were prepared by using superdisintegrants namely, sodium starch glycolate, cro...

The aim of this study was to evaluate the influence of disintegration mechanism of various types of disintegrants on the absorption ratio (AR), wetting time (WT), and disintegration time (DT) of orodispersible tablets (ODTs). ODTs were prepared by direct compression using mannitol as filler and disintegrants selected from a range of swellable, osmotic, and porous disintegrants. Tablets formed w...

The disintegrant potential of native starches of five new cassava (Manihot esculenta Crantz.) varieties developed by the Crops Research Institute of Ghana (CRIG) was studied in paracetamol tablet formulations. The yield of the starches ranged from 8.0 to 26.7%. The starches were basic (pH: 8.1-9.9), with satisfactory moisture content (≤15%), swelling capacity (≥20%), ash values (<1%), flow prop...

We consider volume-preserving perturbations of the time-one map of the geodesic flow of a compact surface with negative curvature. We show that if the Liouville measure has Lebesgue disintegration along the center foliation then the perturbation is itself the time-one map of a smooth volume-preserving flow, and that otherwise the disintegration is necessarily atomic.

Anagandula, M. 2016. Studies of Enterovirus Infection and Induction of Innate Immunity in Human Pancreatic Cells. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1223. 63 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9572-5. Several epidemiological and clinical studies have indicated a possible role of Enterovirus (EV) infection in type 1 dia...

In cell cultures of Detroit 6, KB, and HeLa cells, treatment with certain amounts of 5Fluorouracil resulted in the appearance of a strikingly distinct halo or chromophobic area, entirely encircling the compacted or contracted nucleoli, before the ultimate disintegration of the cells. ∗PMID: 4221925 [PubMed indexed for MEDLINE] Copyright c ©OKAYAMA UNIVERSITY MEDICAL SCHOOL Acta Med. Okayama 19,...

This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels-Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent d...

The aim of this study was to evaluate the glass ionomer cement Ketac-Endo (K) compared with Endofill (E), N-Rickert (N), and Sealer 26 (S) in terms of disintegration, solubility, and dimensional alteration properties, based on ADA Specification No 57. For dimensional alterations, 12-mm high cylindric specimens measuring 6 mm in diameter were prepared and left to stand for a period corresponding...