We have read with interest the observational study by Mahfouz and colleagues (1), who examined the role of cytidine deaminase (CDA) on outcomes of patients treated with 5-azacytidine or decitabine. Surprisingly, gender emerged as themain determinant of CDA levels, and consequently, male patients displayed worse outcome as compared with females. These data donotmatch the results of all previous ...

This article presents empirical tests to examine if the comprehensive development area (CDA) where the town planning is more comprehensive has relatively higher economic values than the area outside CDA. The three hypothesis are: (i) CDAs have less environmental complaints than areas outside CDA; (ii) property sales price variances in CDAs are smaller than those in areas outside CDAs; and (iii)...

The persistence of cellulose diacetate (CDA), a biobased plastic used in textiles and single-use consumer products, the ocean is currently unknown. Here, we probe disintegration degradation CDA-based materials (25 μm films, 510 foam, 97 g/m2 fabric) by marine microbes continuous flow seawater mesocosm. Photographic evidence mass loss measurements demonstrate that disintegrate months. Disintegra...

The present study investigated the development of visuospatial working memory (VSWM) capacity and the efficiency of filtering in VSWM in adolescence. To this end, a group of IQ-matched adults and adolescents performed a VSWM change detection task with manipulations of WM-load and distraction, while performance and electrophysiological contralateral delay activity (CDA) were measured. The CDA is...

PURPOSE OF REVIEW Congenital dyserythropoietic anemias (CDAs) are rare hereditary disorders characterized by ineffective erythropoiesis and by distinct morphological abnormalities of erythroblasts in the bone marrow. Characteristic morphological aberrations were the cornerstone of diagnosis, but following the identification of several causative genes, the molecular approach could represent a ra...

Studies have been conducted with the arginase (l-arginine amidinohydrolase, EC 3.5.3.1) of two legumes: jack bean, Canavalia ensiformis (L.) DC., a l-canavanine-containing plant and soybean, Glycine max, a canavanine-free species. Analyses of the arginase obtained from gradient-purified mitochondria of these legumes revealed that the arginine-dependent (ADA) and canavanine-dependent activities ...

We evaluated the influence of amifostine used alone or in combination with 2-chlorodeoxyadenosine (2-CdA) on the colony growth of normal and chronic myeloid leukemia (CML) granulocyte-macrophage progenitor cells (CFU-GM) in semisolid culture in vitro. Amifostine at a concentration of 1 mg/ml was either added directly to the culture medium of normal and CML CFU-GM, or mononuclear cells (MNCs) we...

Cytosine deaminase (CDA) from E. coli is a member of the amidohydrolase superfamily. The structure of the zinc-activated enzyme was determined in the presence of phosphonocytosine, a mimic of the tetrahedral reaction intermediate. This compound inhibits the deamination of cytosine with a K(i) of 52 nM. The zinc- and iron-containing enzymes were characterized to determine the effect of the dival...

As part of the Discourse Approaches to Politics, Society and Culture series, this volume mainly introduces the interdisciplinary and multi-methodological character of (critical) discourse analysis (CDA). Some of the contributions were further developed through discussion at the workshop on ‘New Agenda in CDA’ that was convened in 2003 at the University of Vienna. The intention of the editors wa...

BACKGROUND AND OBJECTIVE It has been widely demonstrated that one single 7-day course continuous infusion (c.i.) 2-chlorodeoxyadenosine (2-CdA) at a dose of 0.1 mg/kg daily is dramatically effective in inducing high and prolonged complete remission (CR) rates in patients with hairy-cell leukemia (HCL). However, 2-CdA administration often results in severe neutropenia and lymphocytopenia both re...