نتایج جستجو برای: cd98

تعداد نتایج: 235  

Journal: :Journal of investigational allergology & clinical immunology 2010
A Månsson O Bachar M Adner S Björnsson L O Cardell

BACKGROUND The underlying mechanisms of allergen-specific immunotherapy (SIT) are not fully understood. OBJECTIVES The present study aimed to investigate how leukocyte phenotypes are affected by SIT. METHODS Blood samples were taken from 10 patients with birch pollen--induced allergic rhinitis before, during, and immediately after SIT. Further samples were obtained after 1 year and 3 years....

Journal: :Journal of immunology 2009
Mandy Pierau Swen Engelmann Dirk Reinhold Thabo Lapp Burkhart Schraven Ursula H Bommhardt

Protein kinase B (PKB)/Akt signals control T cell proliferation and differentiation but their effect on the generation and function of regulatory T cells (Treg) and Th17 cells is not well understood. In this study, we show that elevated PKB signals antagonize the immunosuppressive effect of TGF-beta1 on cell size, CD25 and CD98 expression, and proliferation of CD3-stimulated naive CD4(+) T cell...

2017
Pey-Jium Chang Yao-Hsu Yang Pau-Chung Chen Lee-Wen Chen Shie-Shan Wang Ying-Ju Shih Li-Yu Chen Chi-Jen Chen Chien-Hui Hung Chun-Liang Lin

Patients with diabetes are generally prone to pathogen infection and tumor progression. Here, we investigated the potential association between diabetes and Kaposi's sarcoma (KS), a tumor linked to infection with Kaposi's sarcoma-associated herpesvirus (KSHV). By using Taiwan's National Health Insurance Research Database, we found that diabetes is statistically associated with increased risk of...

2015
Ersilia Nigro Irene Colavita Daniela Sarnataro Olga Scudiero Gerardo Zambrano Vincenzo Granata Aurora Daniele Alfonso Carotenuto Stefania Galdiero Veronica Folliero Massimiliano Galdiero Richard A. Urbanowicz Jonathan K. Ball Francesco Salvatore Antonello Pessi

Host defence peptides (HDPs) are critical components of innate immunity. Despite their diversity, they share common features including a structural signature, designated "γ-core motif". We reasoned that for each HDPs evolved from an ancestral γ-core, the latter should be the evolutionary starting point of the molecule, i.e. it should represent a structural scaffold for the modular construction ...

2017
David Dickens George N. Chiduza Gareth S. A. Wright Munir Pirmohamed Svetlana V. Antonyuk S. Samar Hasnain

LAT1 (SLC7A5) is a transporter for both the uptake of large neutral amino acids and a number of pharmaceutical drugs. It is expressed in numerous cell types including T-cells, cancer cells and brain endothelial cells. However, mechanistic knowledge of how it functions and its interactions with lipids are unknown or limited due to inability of obtaining stable purified protein in sufficient quan...

Journal: :Cancer research 2014
Soline Estrach Sin-Ae Lee Etienne Boulter Sabrina Pisano Aurélia Errante Floriane S Tissot Laurence Cailleteau Catherine Pons Mark H Ginsberg Chloé C Féral

CD98hc (SLC3A2) is the heavy chain component of the dimeric transmembrane glycoprotein CD98, which comprises the large neutral amino acid transporter LAT1 (SLC7A5) in cells. Overexpression of CD98hc occurs widely in cancer cells and is associated with poor prognosis clinically, but its exact contributions to tumorigenesis are uncertain. In this study, we showed that genetic deficiency of CD98hc...

Journal: :American journal of physiology. Renal physiology 2006
Masao Kakoki Hyung-Suk Kim Cora-Jean S Edgell Nobuyo Maeda Oliver Smithies David L Mattson

To examine the mechanisms whereby amino acids modulate nitric oxide (NO) production and blood flow in the renal vasculature, chemiluminescence techniques were used to quantify NO in the renal venous effluent of the isolated, perfused rat kidney as different amino acids were added to the perfusate. The addition of 10(-4) or 10(-3) M cationic amino acids (l-ornithine, l-lysine, or l-homoarginine)...

2015
Takeshi Kurihara Hideki Arimochi Zaied Ahmed Bhuyan Chieko Ishifune Hideki Tsumura Morihiro Ito Yasuhiko Ito Akiko Kitamura Yoichi Maekawa Koji Yasutomo Simona Stäger

Upon their recognition of antigens presented by the MHC, T cell proliferation is vital for clonal expansion and the acquisition of effector functions, which are essential for mounting adaptive immune responses. The CD98 heavy chain (CD98hc, Slc3a2) plays a crucial role in the proliferation of both CD4+ and CD8+ T cells, although it is unclear if CD98hc directly regulates the T cell effector fun...

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