Using 5 fetuses of gestational age (GA) of 15-16 weeks and 4 of GA of 22-25 weeks, we examined site- and stage-dependent differences in CD68-positive microglial cell distribution in human fetal brains. CD68 positive cells were evident in the floor of the fourth ventricle and the pons and olive at 15-16 weeks, accumulating in and around the hippocampus at 22-25 weeks. At both stages, the accumul...

Cellular neurothekeoma (CNT) is an uncommon variant of neurothekeoma that is composed of pithelioid to spindled cells with variable nuclear atypia or pleomorphism but no myxoid stroma. CNT occurs predominantly in the head and neck or upper trunk of children and young adults, with female predominance. The following case is different from typical CNTs. An 88-year-old female presented with a palpa...

Results Histopathology showed a mostly lobular panniculitis, without vasculitis, with a mixed inflammatory infiltrate with evolving prominent cellularity with neutrophils, then lymphocytes and finally histiocytes. Lipophagia was considered the cause of lipoatrophy. On immunohistochemistry, T-lymphocytes, both CD4 and CD8, were strongly represented, with a higher proportion of CD8. Myeloperoxida...

Clinical trials have proven oncolytic virotherapy to be safe but not effective. We have shown that oncolytic viruses (OV) injected into intracranial gliomas established in rodents are rapidly cleared, and this is associated with up-regulation of markers (CD68 and CD163) of cells of monocytic lineage (monocytes/microglia/macrophages). However, it is unclear whether these cells directly impede in...

BACKGROUND We previously showed that the progression of atherosclerosis in the Reversa mouse (Ldlr(-/-Apob100/100Mttpfl/fl) Mx1Cre(+/+)) was arrested when the hyperlipidemia was normalized by inactivating the gene for microsomal triglyceride transfer protein. Here, we tested whether atherosclerosis would regress if the lipid levels were reduced after advanced plaques formed. METHODS AND RESUL...

We have previously demonstrated that acute treatment with low dose methamphetamine is neuroprotectivein a rat model of severe traumatic brain injury (TBI). Using gene expression analysis, we further showed that methamphetamine treatment significantly reduced the expression of proinflammatory genes after severe TBI. Therefore, to further investigate the potential effects of methamphetamine treat...

section. XXIII Annual meeting of the Latin American association for the study of the liver. , 2014; 13 (5): 601-620 602 (37.45 ± 4.79/HPF, P < 0.001) (Figure 1A). A larger number of MAC387+ monocytes infiltrated livers of CLD patients (40.45 ± 35.17/HPF) than normal tissues (2.45 ± 2.78/HPF, P < 0.001) (Figure 1B). In different etiologies of CLD patients, the CD68+ macrophages and MAC387+ monoc...

BACKGROUND Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) can be classified into; focal, crescentic, mixed and sclerotic classes. Macrophages and T lymphocytes are key players in mediating renal injury. The frequency of macrophage and T lymphocytes in different histological classes is unclear. OBJECTIVES We examined the frequency of macrophage and T lymphocyt...

Our previous study has found that the abundance of peritumoral CD68(+) macrophages was associated with poor prognosis in hepatocellular carcinoma (HCC) after resection. However, CD68 staining could not discriminate the protumoral or tumoricidal subpopulations from pan-macrophages. CD163 is a marker of alternatively activated macrophages. In this study, the clinical significance of CD163(+) cell...

OBJECTIVE To explore the relationship between the number of tumor-associated macrophages (TAMs) and proliferative activity of tumor cells and the relationship between two macrophage biomarkers CD68 and CD163 in nasopharyngeal NK/T-cell lymphoma. METHODS Immunohistochemistry was used to reconfirm the diagnosis of nasal NK/T-cell lymphoma and detect the numbers of TAMs and the ki-67 label index...