We generated 1,090 ATAC-seq and 1,057 T-cell RNA-seq libraries from 153 subjects, derived 8 flow-sorted subsets (defined by CD4/CD8, CLA+/ CLA-, 0/24h CD3/CD28 stimulation). Effects of activation skin-homing were analyzed DESeq2. After peak calling, 78,234 consensus peaks present in ≥ 30 libraries. A Wald test examining simple main effects identified 9,072, 3,934, 21,174 as differentially acces...

in this paper, the multistage variational iteration method is implemented to solve a general form of the system of first-order differential equations. the convergence of the proposed method is given. to illustrate the proposed method, it is applied to a model for hiv infection of cd4+ t cells and the numerical results are compared with those of a recently proposed method.

Introduction Access to CD4+ testing remains a common barrier to early initiation of antiretroviral therapy among persons living with HIV/AIDS in low- and middle-income countries. The feasibility of task-shifting of point-of-care (POC) CD4+ testing to lay health workers in Namibia has not been evaluated. Methods From July to August 2011, Pima CD4+ analysers were used to improve access to CD4+ ...

Background: During antigen capture and processing, mature dendritic cells (DC) express large amounts of peptide-MHC complexes and accessory molecules on their surface. DC are antigen-presenting cells that have an important role in tolerance and autoimmunity. The transforming growth factor-beta1 (TGF-β1) cytokine has a regulatory role on the immune and non-immune cells. The aim of this study is ...

HIV infection is a chronic disease in which different endocrine glands could be involved either directly by the virus itself or indirectly by many factors especially oportunistic infections at the late stages of the disease. bacause the duration and the manifestations of the infection is related to the General factors, we evaluated the hypophysial, thyroid, adrenal and the gonadal hormones in 1...

Background: Androgenic hair loss (AGA) and alopecia areata (AA) are common conditions which sometimes are histologically difficult to differentiate. This study was conducted to detect differentiating features of these two disorders with IHC analysis of T-cell subsets in the inflammatory infiltrates of alopecia areata and androgenetic alopecia. Methods: This cr...

The current study aimed to investigate the effectiveness of Elephantopus scaber and Sauropus androgynus as anti-inflammatory agents in pregnant mice infected with Escherichia coli. This used seven treatments group (n=3): K- (healthy mice), K+ (pregnant E. coli), P1 coli + 100%), P2 75% S. 25%), P3 50% 50%), P4 25% 75%), P5 100%). Flow cytometry analysis was analyze cell populations expressing C...