Introduction Access to CD4+ testing remains a common barrier to early initiation of antiretroviral therapy among persons living with HIV/AIDS in low- and middle-income countries. The feasibility of task-shifting of point-of-care (POC) CD4+ testing to lay health workers in Namibia has not been evaluated. Methods From July to August 2011, Pima CD4+ analysers were used to improve access to CD4+ ...

Background: During antigen capture and processing, mature dendritic cells (DC) express large amounts of peptide-MHC complexes and accessory molecules on their surface. DC are antigen-presenting cells that have an important role in tolerance and autoimmunity. The transforming growth factor-beta1 (TGF-β1) cytokine has a regulatory role on the immune and non-immune cells. The aim of this study is ...

HIV infection is a chronic disease in which different endocrine glands could be involved either directly by the virus itself or indirectly by many factors especially oportunistic infections at the late stages of the disease. bacause the duration and the manifestations of the infection is related to the General factors, we evaluated the hypophysial, thyroid, adrenal and the gonadal hormones in 1...

Background: Androgenic hair loss (AGA) and alopecia areata (AA) are common conditions which sometimes are histologically difficult to differentiate. This study was conducted to detect differentiating features of these two disorders with IHC analysis of T-cell subsets in the inflammatory infiltrates of alopecia areata and androgenetic alopecia. Methods: This cr...

The current study aimed to investigate the effectiveness of Elephantopus scaber and Sauropus androgynus as anti-inflammatory agents in pregnant mice infected with Escherichia coli. This used seven treatments group (n=3): K- (healthy mice), K+ (pregnant E. coli), P1 coli + 100%), P2 75% S. 25%), P3 50% 50%), P4 25% 75%), P5 100%). Flow cytometry analysis was analyze cell populations expressing C...

Dermatomyositis (DM) is a chronic, systemic autoimmune disease affecting the skin, muscle, and lungs. Lenabasum, non-psychoactive cannabinoid type 2 receptor (CB2R) agonist, currently being investigated as non-immunosuppressive treatment option for DM. The activation of CB2R has been shown to reduce several key pro-inflammatory cytokines implicated in Our lab previously demonstrated via immunoh...

Unter dem Begriff der kutanen T-Zell-Lymphome (CTCL) wird eine Gruppe lymphoproliferativer Erkrankungen zusammengefasst, die durch Lokalisation neoplastischer T-Lymphozyten in Haut gekennzeichnet sind. Die Mycosis fungoides (MF) ist häufigste Form von CTCL; sie macht ∼60 % aller primären Lymphome aus. Neben klassischen MF sind zahlreiche klinische und histopathologische Varianten beschrieben wo...

In order to develop a biomarker predicting the efficacy of treatments for patients with esophageal squamous cell carcinoma (ESCC), we evaluated subpopulation T cells in ESCC treated chemotherapy (CT), chemoradiotherapy (CRT), and nivolumab therapy (NT). Fifty-five were enrolled this study, peripheral blood samples collected before after CT or CRT during NT. Frequencies memory, differentiated, e...