نتایج جستجو برای: cd20

تعداد نتایج: 4923  

2014
Magdalena Winiarska Kamil Bojarczuk Beata Pyrzynska Jacek Bil Marta Siernicka Michal Dwojak Malgorzata Bobrowicz Nina Miazek Piotr Zapala Agnieszka Zagozdzon Magdalena Krol Aleksandra Syta Paulina Podszywalow-Bartnicka Zofia Pilch Anna Dabrowska-Iwanicka Przemyslaw Juszczynski Dimitar G Efremov Mikolaj Slabicki Thorsten Zenz Aude Le Roy Daniel Olive Tomasz P Rygiel Jeanette HW Leusen Jakub Golab

Clinical trials with SRC family kinases (SFKs) inhibitors used alone or in a combination with anti-CD20 monoclonal antibodies (mAbs) are currently underway in the treatment of B-cell tumors. However, molecular interactions between these therapeutics have not been studied so far. A transcriptional profiling of tumor cells incubated with SFKs inhibitors revealed strong downregulation of MS4A1 gen...

Journal: :Journal of immunology 2014
Nisar A Baig Ronald P Taylor Margaret A Lindorfer Amy K Church Betsy R LaPlant Adam M Pettinger Tait D Shanafelt Grzegorz S Nowakowski Clive S Zent

Ofatumumab (OFA), a human CD20-targeting mAb, kills B lymphocytes using the innate immune system including complement-dependent cytotoxicity (CDC). The efficacy of OFA in patients with chronic lymphocytic leukemia (CLL) is limited by drug resistance, which is not well characterized. To better understand mechanisms of resistance, we prospectively studied CLL cells isolated from blood samples col...

Journal: :Blood 2010
Bart A Nijmeijer Marianke L J van Schie Constantijn J M Halkes Marieke Griffioen Roelof Willemze J H Frederik Falkenburg

B-lineage acute lymphoblastic leukemia (ALL) may express CD52 and CD20. Alemtuzumab (ALM) and rituximab (RTX) are therapeutic antibodies directed against CD52 and CD20, respectively, but showed limited activity against ALL in clinical trials. The mechanisms for the impaired responses remained unclear. We studied expression of CD52 and CD20 on ALL cells and found that most cases coexpressed CD52...

Journal: :Haematologica 2010
Sébastien Maury Françoise Huguet Thibaut Leguay Francis Lacombe Marc Maynadié Sandrine Girard Adrienne de Labarthe Emilienne Kuhlein Emmanuel Raffoux Xavier Thomas Patrice Chevallier Agnès Buzyn André Delannoy Yves Chalandon Jean-Paul Vernant Philippe Rousselot Elizabeth Macintyre Norbert Ifrah Hervé Dombret Marie-Christine Béné

The prognostic significance of CD20 expression in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) has been mostly studied in children and yielded conflicting results. In 143 adults with Philadelphia chromosome-negative BCP-ALL treated in the multicentric GRAALL 2003 trial, CD20 positivity over 20% was observed in 32% of patients. While not influencing complete remission achievement, CD2...

Journal: :The Journal of Experimental Medicine 1988
I Stamenkovic B Seed

Two cDNA clones encoding the pan-B cell CD20 antigen were isolated from a COS cell expression library. The two clones bear identical coding sequences and differ only in the length of the 3' untranslated region. The predicted CD20 sequence is 297 residues long and contains three hydrophobic domains, one of which is long enough to span the membrane twice. COS cells transfected with either CD20 cl...

Journal: :Journal of neuropathology and experimental neurology 2011
Yolanda S Kap Jan Bauer Nikki van Driel Wim K Bleeker Paul W H I Parren Evert-Jan Kooi Jeroen J G Geurts Jon D Laman Jenny L Craigen Erwin Blezer Bert A 't Hart

This study investigated the effect of CD20-positive B-cell depletion on central nervous system (CNS) white and gray matter pathology in experimental autoimmune encephalomyelitis in common marmosets, a relevant preclinical model of multiple sclerosis. Experimental autoimmune encephalomyelitis was induced in 14 marmosets by immunization with recombinant human myelin oligodendrocyte glycoprotein i...

2016
Capucine L. Grandjean Fabricio Montalvao Susanna Celli David Michonneau Beatrice Breart Zacarias Garcia Mario Perro Olivier Freytag Christian A. Gerdes Philippe Bousso

Anti-CD20 monoclonal antibodies (mAbs) represent an effective treatment for a number of B cell malignancies and autoimmune disorders. Glycoengineering of anti-CD20mAb may contribute to increased anti-tumor efficacy through enhanced antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADP) as reported by in vitro studies. However, where and how glycoengineered Ab may potentiate ther...

2015
Dae-Young Kim Han-Seung Park Eun-Ji Choi Jung-Hee Lee Je-Hwan Lee Mijin Jeon Young-Ah Kang Young-Shin Lee Miee Seol Young-Uk Cho Seongsoo Jang Hyun-Sook Chi Kyoo-Hyung Lee Chan-Jeoung Park

BACKGROUND Efforts to overcome poor outcomes in patients with adult acute lymphoblastic leukemia (ALL) have focused on combining new therapeutic agents targeting immunophenotypic markers (IPMs) with classical cytotoxic agents; therefore, it is important to evaluate the clinical significance of IPMs. METHODS Baseline characteristics and clinical outcomes of patients with adult ALL were retrosp...

ژورنال: :مجله دانشگاه علوم پزشکی زنجان 0
وحیده احمد زاده v ahmadzadeh صفر فرج نیا s farajnia محمد علی حسینپور فیضی ma hosseinpour feizi رمضانعلی خاوری نژاد ra khavarinejad

زمینه و هدف: رتوکسی مب (rituximab) آنتی بادی مونوکلونال کایمریک بر ضد آنتی ژن cd20 بوده، به طور گسترده برای درمان لنفومای سلول های b استفاده می گردد. با این وجود سایز بزرگ و ایمنی زایی آنتی بادی های کامل موشی همواره به عنوان مشکل در ایمونوتراپی مطرح بوده است. جهت حل این مشکل می توان از قطعات کوچک آنتی بادی انسانی شده استفاده نمود. هدف از این تحقیق تولید آنتی بادی تک زنجیره ای انسانی به منظور کا...

2016
Xuejuan Wang Zhi Yang Baohe Lin Yan Zhang Shizhen Zhai Qichao Zhao Qing Xie Fei Liu Xuedi Han Jinfeng Li Tao Ouyang

PURPOSE We aimed to develop and translate a CD20-antigen-targeted radiopharmaceutical, Technetium-99 m-labeled (99mTc) rituximab, for sentinel lymph node (SLN) detection. METHODS 99mTc-rituximab was synthesized and tested for stability in human serum. The binding affinity to CD20 was evaluated in Raji cells by flow cytometric analysis. Biodistribution and sentinel node mapping were carried ou...

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