BACKGROUND We previously reported a delayed phase of protection against infarction 24 hours after ischemic preconditioning in the rabbit. In the present study, we investigated the possibility that this "second window of protection," like the well-described early phase of protection in the rabbit, might be associated with adenosine receptor activation. METHODS AND RESULTS In the first series o...

Streptococcus gordonii and Veillonella atypica, two early-colonizing members of the dental plaque biofilm, participate in a relationship that results in increased transcription of the S. gordonii gene amyB, encoding an alpha-amylase. We show that the transcription factor CcpA is required for this interspecies interaction.

Staphylococcus aureus is a leading cause of community-associated and nosocomial infections. Imperative to the success of S. aureus is the ability to adapt and utilize nutrients that are readily available. Genomic sequencing suggests that S. aureus has the genes required for synthesis of all twenty amino acids. However, in vitro experimentation demonstrates that staphylococci have multiple amino...

Fenton RA, Shea LG, Doddi C, Dobson JG, Jr. Myocardial adenosine A1-receptor-mediated adenoprotection involves phospholipase C, PKC-ε, and p38 MAPK, but not HSP27. Am J Physiol Heart Circ Physiol 298: H1671–H1678, 2010. First published April 2, 2010; doi:10.1152/ajpheart.01028.2009.—Adenosine via an adenosine A1 receptor (A1R) is a negative feedback inhibitor of adrenergic stimulation in the he...

The aminotransferase IlvE was implicated in the acid tolerance response of Streptococcus mutans when a mutation in its gene resulted in an acid-sensitive phenotype (B. Santiago, M. MacGilvray, R. C. Faustoferri, and R. G. Quivey, Jr., J. Bacteriol. 194:2010-2019, 2012). The phenotype suggested that amino acid metabolism is important for acid adaptation, as turnover of branched-chain amino acids...

NanI Sialidase, CcpA and CodY Work Together to Regulate Epsilon Toxin 1 Production by Clostridium perfringens Type D Strain CN3718 2 3 Jihong Li, John C. Freedman and Bruce A. McClane* 4 Department of Microbiology and Molecular Genetics, University of Pittsburgh School of 5 Medicine, Pittsburgh, PA, USA 15219 6 7 8 Running title: C. perfringens NanI regulates ETX production 9

The release of the neurotransmitter norepinephrine (NE) is modulated by presynaptic adenosine receptors. In the present study we investigated the effect of a partial activation of this feedback mechanism. We hypothesized that partial agonism would have differential effects on NE release in isolated hearts as well as on heart rate in vivo depending on the genetic background and baseline sympathe...

Maltose metabolism and the regulation of the glv operon of Bacillus subtilis, comprising three genes, glvA (6-phospho-alpha-glucosidase), yfiA (now designated glvR), and glvC (EIICB transport protein), were investigated. Maltose dissimilation was dependent primarily upon the glv operon, and insertional inactivation of either glvA, glvR, or glvC markedly inhibited growth on the disaccharide. A s...

The computer science literature on identification of people using personal information paints a wide spectrum, from aggregate that doesn’t contain about individual people, to itself identifies person. However, privacy laws and regulations often distinguish between only two types, called personally identifiable de-identified information. We show the collapse this technological spectrum identifia...