Abstract Chronic beryllium disease (CBD) is an inflammatory lung disorder caused by the recruitment and expansion of pathogenic CD4 T cells. In a murine model Be-disease, we reported accumulation CCL3/Be CCL4/Be-specific cells in lungs BeO-exposed HLA-DP2 Tg mice (WT). However, addition single dose LPS on day 14 (d14) WT mice, resulted significant increase release chemokines (CCL3 CCL4), increa...

BACKGROUND Fasting has been recently discovered to improve overall health, but its beneficial effects in the presence of hepatic insufficiency have not been proven. AIM The influence of fasting on the metabolism, immunological aspects, and oxidative stress of 40 male carbon tetrachloride (CCl4)-intoxicated Wistar rats was investigated in the present study. METHODS The rats were divided into...

The aim of this research was to know whether beetroot (Beta Vulgaris) extract could protect spermatogenesis by maintaining spermatogenic and sertoli cell count in rats (Rattus novergicus) induced with CCl4. Rats were given daily, for 14 days 3ml/kg BW CCl4 intraperitoneally one hour after last treatment. This study used twenty which devided equally into 5 groups. K(-), the negative control grou...

Purpose: To determine the in vivo and vitro hepatoprotective effects of Ficus carica.Methods: The methanol leaf extract carica L was further fractionated into n-hexane, ethyl acetate aqueous fractions. For study, male albino mice were divided twelve groups. Hepatotoxicity induced using carbon tetrachloride (CCl4). F. its fractions administered at doses 200 400 mg/kg. Silymarin used as standardh...

Different parts of Icacina trichanta has been used for ethnomedicinal purposes; this study was undertaken to investigate the effects plant on CCl4- induced renal damage. Phytochemical analyses were carried out powdered sample using standard procedures. Absolute organ weight, Urea, creatinine, total protein, superoxide dismutase, catalase and malondialdehyde levels determined. Consequently, thir...

Cytochrome c oxidase was purified from control and CCl4 treated rats and its kinetic properties were studied. The activity of the enzyme was inhibited by 51% in CCl4 (4 g per kg body weight for 24 hr) treated rats. Studies on the kinetic properties showed that the K(m) of the enzyme increased by 60% while Vmax decreased by 44% in CCl4 treated rats compared to controls. The content of cytochrome...

A purified saponin mixture (PSM) isolated from Astragalus corniculatus Bieb. (Fabaceae) was investigated for its protective effect in two models of toxicity, carbon tetrachloride (CCl4) and tert-butyl hydroperoxide (t-BuOOH), using isolated rat hepatocytes. CCl4 undergoes dehalogenation in the liver endoplasmic reticulum. This process leads to trichlormethyl radical (CCl3) formation, initiation...

The role of Nigella Sativa (NS) was investigated in the prevention of carbon tetrachloride (CCl4) induced liver fibrosis. Twenty seven adult wistar-albino rats were allocated into three groups (control, CCl4-induced hepatotoxicity and hepatotoxicity and NS-treated) and after the treatment, rats were sacrified, blood samples were collected for determination of plasma aminotransferases, malondial...

The effect of aqueous ethanol (1:1) extract of the calyx of Hibiscus sabdariffa on carbon tetrachloride (CCl4) induced liver damage was investigated. Oral administration of the extract following a single CCl4 dose promoted the healing of oxidative liver damage as determined by serum aminotransferases, ALT, AST, levels and liver thiobarbituric acid reactive substances levels. It appeared from th...

objective(s):  protective effects of different extracts and essential oil from pimpinella anisum           l. seeds were examined against carbon tetrachloride (ccl4)-induced toxicity. the parameters such as serum transaminases, lactate dehydrogenase activity, hepatic glutathione content, liver lipid peroxidation and histopathological changes of liver were assessed as toxicity markers. in the in...