Bismutine, BiH3, is the least stable of the group15 trihydrides. F. Paneth first detected it in minute traces in 1918 using a radiochemical technique involving Bi2Mg3 [1]. The best preparation method seems to be the one proposed by Amberger in 1961, based on the disproportionation of CH3BiH2 at −45 ◦C[̃2]. This relatively complex synthesis has recently been successfully reproduced and allowed to...

In the ubiquitin-proteasome system (UPS), E2 enzymes mediate the conjugation of ubiquitin to substrates and thereby control protein stability and interactions. The E2 enzyme hCdc34 catalyzes the ubiquitination of hundreds of proteins in conjunction with the cullin-RING (CRL) superfamily of E3 enzymes. We identified a small molecule termed CC0651 that selectively inhibits hCdc34. Structure deter...

Correlating target engagement with in vivo drug activity remains a central challenge in efforts to improve the efficiency of drug discovery. Previously we described a mechanistic pharmacokinetic-pharmacodynamic (PK/PD) model that used drug-target binding kinetics to successfully predict the in vivo efficacy of antibacterial compounds in models of Pseudomonas aeruginosa and Staphylococcus aureus...

N. Fisichelli ([email protected]), K. Rice, C. Buschena and P. Reich , Dept of Forest Resources, Univ. of Minnesota, St. Paul, MN 55108, USA. Present address for NF: Natural Resource Stewardship and Science, US National Park Service, Fort Collins, CO 80525, USA. PR also at: Hawksbury Inst. for the Environment, Univ. of Western Sydney, Penrith, NSW 2753, Australia. – A. Wright, German Centre...

Tanah lempung kurang baik dijadikan tanah dasar pembangunan jalan sehingga perlu distabilisasi dengan kapur agar memperbaiki sifat fisis lempung. Tujuan penelitian yaitu melakukan Pengujian Sifat Fisis Lempung variasi penambahan kapur, analisis terhadap hasil uji tohor (CaO) dan stabilitas berdasarkan yang dilakukan. Metode adalah metode eksperimen pengujian laboratorium meliputi konsistensi at...

INTRODUCTION We aimed to describe the distribution of radiographic chondrocalcinosis (CC) and to examine whether metacarpophalangeal joint (MCPJ) calcification and CC at other joints occurs in the absence of knee involvement. METHODS This was a cross-sectional study embedded in the Genetics of Osteoarthritis and Lifestyle study (GOAL). All participants (n = 3,170) had radiographs of the knees...