BACKGROUND/AIMS In assigning patients with chronic obstructive pulmonary disease (COPD) to subgroups according to the updated guidelines of the Global Initiative for Chronic Obstructive Lung Disease, discrepancies have been noted between the COPD assessment test (CAT) criteria and modified Medical Research Council (mMRC) criteria. We investigated the determinants of symptom and risk groups and ...

Various families of tolerance graphs of subtrees for specific families of host trees and tolerance functions have been successfully characterized. For example, chordal graphs are intersection (tolerance 1) graphs of subtrees of general trees, see [2], [5], and [8]. Intersection graphs of subtrees of a path are those that are chordal and do not contain an asteroidal triple, see [7]. We denote by...

cat-86 is a plasmid gene specifying chloramphenicol-inducible chloramphenicol acetyltransferase activity in Bacillus subtilis. Inducibility has been suggested to result primarily from activation of the translation of cat-86 mRNA by subinhibitory levels of chloramphenicol. To directly test the involvement of transcription in cat-86 induction, the gene was transcriptionally activated with a stron...

This paper proposes that business CAT be introduced as the reform of a course in Chinese universities. Firstly, the authors describe the conceptual framework and design of business CAT course and textbook, the newly developed “Computer-Aided Business Translation Teaching System (Business CAT), with a focus on learner translation training and teacher management platforms. Secondly, the authors d...

We compared a rigid (1-h) screening method for the detection of chloramphenicol acetyltransferase (CAT) activity with the standard spectrophotometric CAT assay to determine whether CAT-mediated chloramphenicol resistance in Haemophilus influenzae could be determined upon primary isolation. Of 58 H. influenzae cell sonicates, 28 had detectable CAT activity when the chloramphenicol-dependent prod...

We have developed a novel Saccharomyces cerevisiae model system to dissect the molecular events of beta-catenin (beta-cat) signaling. Coexpression of mammalian beta-cat with TCF4 or LEF1 results in nuclear accumulation of these proteins and a functional complex that activates reporter gene transcription from constructs containing leukocyte enhancer factor (LEF)/T cell factor (TCF) response elem...

Purpose. The transcellular arginine transportation via cationic amino acid transporter (CAT) is the rate-limiting step in nitric oxide (NO) synthesis, which is crucial in intraocular inflammation. In this study, CAT isoforms and inducible nitric oxide synthase (iNOS) expression was investigated in endotoxin-induced uveitis (EIU). Methods. EIU was induced in Lewis rats by lipopolysaccharide (LPS...

AIMS We have investigated Ca²(+) signalling generated by aldosterone-induced T-type current (I(CaT)), the effects of I(CaT) in neonatal cardiomyocytes, and a putative role for I(CaT) in cardiomyocytes during cardiac pathology induced by stenosis in an adult rat. METHODS AND RESULTS Neonatal rat cardiomyocytes treated with aldosterone showed an increase in I(CaT) density, principally due to th...

To evaluate the usefulness of computerized adaptive testing (CAT) in medical school, the General Examination for senior medical students was administered as a paper and pencil test (P&P) and using CAT. The General Examination is a graduate examination, which is also a preliminary examination for the Korean Medical Licensing Examination (KMLE). The correlations between the results of the CAT and...

BACKGROUND The COPD Assessment Test (CAT) is responsive to change in patients with chronic obstructive pulmonary disease (COPD). However, the minimum clinically important difference (MCID) has not been established. We aimed to identify the MCID for the CAT using anchor-based and distribution-based methods. METHODS We did three studies at two centres in London (UK) between April 1, 2010, and D...