Preeclampsia (PE) is a severe pregnancy-specific complication responsible for majority of maternal and fetal mortality. The dysfunction trophoblast cells known to be associated with the etiology PE. Moreover, elevated expression hsa_circ_0001326 was found in patients PE without elucidating specific mechanisms. Thus, this study aimed investigate role vitro. Human SWAN71 were used study. Cell pro...

Abstract Background Preeclampsia (PE) is a pregnancy related disease that affects about 5% of pregnancies. Death receptor 3 (DR3) expression significantly elevated in both placental tissue and plasma PE patients. However, whether DR3 was involved trophoblasts pathogenesis are not well elucidated. Objective Our research designed to illustrate the biological roles trophoblasts, as explain its rel...

endoplasmic reticulum (er) stress provides abnormalities in insulin action, inflammatory responses, lipoprotein b100 degradation and hepatic lipogenesis. excess accumulation of triglyceride in hepatocytes may also lead to disorders such as non-alcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash). opioid peptides are involved in triglyceride and cholesterol dysregulat...

Platinum based combined chemotherapy have been proved to be the most effective drugs for ovarian cancer treatment, but it is difficult treat cisplatin resistant cancer. Carbobenzoxy-L-leucy-L-Leucyl-L-Leucinal (MG132) a reversible tripeptide aldehyde proteasome inhibitor, purpose of this study was observe effect MG132 on SKOV3 cell and OVCAR-3 expression autophagy apoptosis related factors. The...

Introduction: Cancer can be defined as an illness of reformed gene expression. There are numerous agents affecting expression and altering cellular activities. Nanotechnology has offered the possibility modulating tumor suppressor genes’ expression, improving kinetics gene-targeted therapeutics, simplifying drug delivery to tumors across bio-complexes.Methods: Gene expressions caspase3, 8 9, Ba...

Stevens-Johnson syndrome (SJS)/ toxic epidermal necrolysis (TEN) are characterized by the remarkable cell death of keratinocytes. Recently, PANoptosis, in which multiple regulated deaths (RCDs) occur simultaneously, is revealed to be involved pathogenesis various diseases. Although PANoptosis an infection defense response, whether keratinocytes equipped with this function not clarified. The pur...

Stem cells are extensively used for regenerative purposes as they unspecialized capable of renewal and differentiation. Growth factors like vascular endothelial growth factor (VEGF) play a crucial role in enhancing the potential stem cells. The present study was designed to elucidate effects VEGF preconditioning accelerating adipose-derived (ADSCs) wound healing. In vivo carried out using femal...