Previous in vivo studies have shown that beta-alanine is incorporated specifically into the dipeptide L-carnosine (beta-alanyl-L-histidine). In the present study, we administered beta-[3H]alanine to the nasal cavity of hamsters and used biochemical analyses to identify the radioactively labeled compounds in the olfactory epithelium and olfactory bulb and autoradiography to demonstrate the local...

Anserine (beta-alanyl-N(Pi)-methyl-L-histidine), a naturally occurring derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of skeletal muscles and brain of many vertebrates. Although it has long been proposed to serve as a proton buffer, radicals scavenger and transglycating agent, its physiological function remains obscure. The formation of anserine is catalyzed by ca...

Our knowledge of carnosine is largely due to the admirable investigations of Gulewitsch. The discovery of the base in beef muscle extract was first reported by Gulewitsch and Amiradiib? in 1900. Later Kutsche? isolated a substance from beef muscle extract, which he named ignotine, but Gulewitscl? showed that ignotine and carnosine were identical. In the same volume, he4 showed that hydrolysis o...

Interstitial K+ ([K+]i) was measured in human skeletal muscle by microdialysis during exhaustive leg exercise, with (AL) and without (L) previous intense arm exercise. In addition, the reproducibility of the [K+]i determinations was examined. Possible microdialysis-induced rupture of the sarcolemma was assessed by measurement of carnosine in the dialysate, because carnosine is only expected to ...

Since it was shown in a previous report (1) that certain peptidases were capable of hydrolyzing peptides containing @alanine, the present investigation was undertaken to determine the possible metabolic fate of the naturally occurring peptide, carnosine. Although this substance, /3-alanyl-Lhistidine, has long been known and is one of the most abundant of the non-protein nitrogenous constituents...

INTRODUCTION Ageing of populations globally, coupled with the obesity epidemic, has resulted in the rising prevalence of chronic diseases including diabetes, cardiovascular diseases, cancers and neurodegenerative disorders. Prevention of risk factors that contribute to these diseases is key in managing the global burden of chronic diseases. Recent studies suggest that carnosine, a dipeptide wit...

A-Alanine is rapidly developing as one of the most popular sport supplements used by strength/power athletes worldwide. The popularity of A-alanine stems from its unique ability to enhance intramuscular buffering capacity and thereby attenuating fatigue. This review will provide an overview of the physiology that underlies the mechanisms of action behind A-alanine, examine dosing schemes, and e...


 Carnosine (β-alanyl-L-histidine) was first isolated from meat extracts by Russian scholars in 1900. Carnosine is now recognized as an anti-aging chelator/antioxidant with non-enzymatic free radical scavenging properties and serves as an immunomodulator and neuroprotector molecule. It is a naturally-occurring (endogenously synthesized) dipeptide present in brain, cardiac muscle, stomach, kidne...

Background: Carnosine is a dipeptide molecule (?-alanyl-l-histidine) with anti-inflammatory, antioxidant, anti-glycation, and chelating properties. It used in exercise physiology as food supplement to increase performance; however, vitro evidence suggests that carnosine may exhibit anti-cancer Methods: In this study, we investigated the effect of on breast, ovarian, colon, leukemic cancer cell ...

In this paper, authors summarise studies refferering to enrichment of breast and thigh muscles with carnosine that has an important function in physiological processes. Research shown improves quality chicken meat. By adding amino acids β-alanine L-histidine chickens’ feed, synthesizes skeletal muscles, brain, heart muscle olfactory receptor cells. It been determined the content depends on type...