Carnitine is involved in fatty acid metabolism in mammals and is widely used as a nutritional supplement; carnitine orotate is a more absorbable form of carnitine. We investigated the effects of carnitine and carnitine orotate on mouse prolactin-releasing peptide (PrRP) mRNA expression. Twenty-four female mice were randomly divided into four groups of six; control mice were orally drenche...

Radioisotopic analyses for carnitine content were done on infant formula, formulas for tube feeding, food supplements, and chemically defined diets. The carnitine content of the diets depend on the protein source. Products whose main protein source is soy protein isolate, casein, or egg white solids contain 4 nmole carnitine per milliliter or less, with most of them containing undetectable amou...

A trial was conducted to biochemically explain the decreased lipid deposition and increased protein accretion observed in pigs fed carnitine. Our hypothesis was that an increase in the ratio of acetyl CoA:CoA-SH produced by stimulation of fatty acid oxidation by supplemental L-carnitine may decrease branched-chain alpha-keto acid dehydrogenase activity and increase pyruvate carboxylase activity...

Tian M., Wang N., Su G., Shi B., Shan A. (2017): Effects of dietary l-carnitine and fat type on the performance, milk composition and immunoglobulin in sows, and immunological variables of sows and piglets during late gestation and lactation. Czech J. Anim. Sci., 62, 185–194. An experiment with a 2 × 2 factorial arrangement of treatments (n = 12 sows/treatment) was conducted to investigate the ...

Objective: Due to the lack of information about the positive or negative effects of L-carnitine, chromium, vitamin D, and the uptake of a safe dietary supplement to reduce the effects of diabetes, it seems essential to determine the effects of these drugs on diabetes. Materials and Methods: Wistar rats were divided into 12 groups, control, diabetic, and intact, each of which was treated with m...

Prodrugs that liberate pivalate (trimethylacetic acid) after hydrolysis have been developed to improve the bioavailability of therapeutic candidates. Catabolism of pivalate released by activation of a prodrug is limited in mammalian tissues. Pivalate can be activated to a coenzyme A thioester in cells. In humans, formation and urinary excretion of pivaloylcarnitine generated from pivaloyl-CoA i...

to investigate the effect of dietary supplementation of l-carnitine on resistance to temperature and salinity stresses in sobaity fry, an experiment was carried out with 240 pieces of fish with average initial weight of 3.01±0.03 g for 10 weeks. experimental treatments were consisted of four levels of 0, 500, 1000 and 1800 (respectively control, lc500, lc1000 and lc1800) mg l-carnitine per kg o...

background systemic carnitine deficiency may present with apnea, hypotonia, and poor growth. premature infants often manifest these symptoms and are at risk of developing carnitine deficiency because of immaturity of the biosynthetic pathway, lack of sufficient predelivery transplacental transport, and lack of sufficient exogenous supplementation. objective this study was undertaken to examine ...

Aim: We measured carnitine levels in patients with carnitine including dialysis patients, and examined whether administration of L-carnitine improved muscle symptoms. Methods: We measured carnitine levels in 27 patients with liver cirrhosis who were receiving treatment in our hospital, and administered L-carnitine (600 mg 1800 mg) to patients having muscle cramps for approximately one month and...