Insulin and insulin-like growth factor stimulate protein synthesis cardioprotection in the heart, acting through their receptors (INSRs, IGF1Rs) signalling via kinase B (PKB, also known as Akt). Protein is increased hearts perfused at alkaline pHo to same extent with insulin. Moreover, ?1-adrenergic receptor (?1-AR) agonists (e.g. phenylephrine) increase cardiomyocytes, activating PKB/Akt. In b...

AbstractBackground and aims Coronary heart disease is a major global health concern. Further, severity of this condition greatly influenced by myocardial ischemia/reperfusion (I/R) injury. Branched-chain amino acids (BCAAs) have cardioprotective effects against I/R via mammalian target rapamycin (mTOR) activity, wherein Leu considered to particularly regulate mTOR activation. ...

Ischaemic preconditioning confers strong protection against myocardial ischaemia–reperfusion injury. Although its therapeutic application in the case of acute coronary syndromes is not possible in general, the cellular and molecular processes leading to preconditioning protection may be of interest for the designing of cardioprotective therapies. Many cellular processes have been shown to be in...

Using two-dimensional electrophoresis, mass spectrometry, immunoblotting, and affinity pull-down assays, we found that myocardial protein kinase C e (PKCe) is physically associated with at least 36 known proteins that are organized into structural proteins, signaling molecules, and stress-responsive proteins. Furthermore, we found that the cardioprotection induced by activation of PKCe is coupl...