Background Although the left ventricle is the major site of BNP secretion in response to cardiac pressure or volume overload, the myocytes of both atria and ventricles secrete B- type natriuretic peptide (BNP). This study aimed to assess and compare the plasma levels of BNP in common pediatric cardiac diseases to clarify its pathophysiological role and evaluate its po...

Background:This study investigated the effects of age on outcomes coronavirus disease 2019 (COVID-19) and cardiac biomarker profiles, especially in patients with cardiovascular diseases and/or risk factors (CVDRF).

Cardiac catheterization was done for the first time 25 years ago by Forssman,’ who performed the maneuver on himself. However, this procedure was employed in the study and diagnosis of heart disease only after Cournand and Ranges2 demonstrated the value and safety of the method in 1941. The method was subsequently completed by the addition of several collateral techniques. The most useful appli...

Numerous conditions promote oxidative stress, leading to the build-up of reactive aldehydes that cause cell damage and contribute to cardiac diseases. Aldehyde dehydrogenases (ALDHs) are important enzymes that eliminate toxic aldehydes by catalysing their oxidation to non-reactive acids. The review will discuss evidence indicating a role for a specific ALDH enzyme, the mitochondrial ALDH2, in c...

Mechanosensitivity is essential for heart function just as for all other cells and organs in the body, and it is involved in both normal physiology and diseases processes of the cardiovascular system. In this review, we have outlined the relationship between mechanosensitivity and heart physiology, including the Frank-Starling law of the heart and mechanoelectric feedback. We then focused on mo...

470 Extracardiac endothelium patterns embryonic coronary arterio-venous connections JM. Perez-Pomares1; E. Cano2; R. Carmona1; A. Ruiz-Villalba3; A. Rojas4; Y-Y. Chau5; KD. Wagner6; N. Wagner6; ND. Hastie5; R. Munoz-Chapuli1 University of Málaga, Málaga, Spain; Max Delbruck Center for Molecular Medicine, Berlin, Germany; University of Navarra, Pamplona, Spain; Centro Andaluz de Biologı́a Molecul...

Proteomic profiles of myocardial tissue in two different etiologies of heart failure were investigated using high performance liquid chromatography (HPLC)/Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Right atrial appendages from 10 patients with hemodynamically significant isolated aortic valve disease and from 10 patients with isolated symptomatic coronary heart dis...

Left ventricular hypertrophy (LVH) is highly prevalent in kidney transplant recipients and is associated with poor clinical outcome. Immunosuppressive agents might affect LVH behavior after kidney transplantation. This review is an appraisal of available data regarding LVH in renal transplantation and especially of studies that evaluated LVH response to treatment. In particular, the role of mam...