Abstract: Objectives: The ambition of this study is to find the mucoadhesive assets Pistacia lentiscus plant gum (mastic gum) by combining it into microspheres with Amoxicillin Trihydrate (ATH). Significance: Due its short stomach residence duration, ATH efficient against H. pylori but can be improved creating Mucoadhesive Microspheres (MMS) that keep trihydrate in stomach. In study, has been e...

PURPOSE To investigate the interpolymer complexation between Carbopol 934P (CP) and various grades of polyvinylpyrrolidone (PVP) (K90, K32, C15, and VA/S-630). METHODS Amount of fresh and dried CP-PVP complexes, water retaining capacity, apparent density, pH, conductivity, FTIR, swelling and adhesion strength were studied. RESULTS Interpolymer complexation occurred between CP and all the PV...

Pyrosequencing of the 16S ribosomal RNA gene (16S) has become one of the most popular methods to assess microbial diversity. Pyrosequencing reads containing ambiguous bases (Ns) are generally discarded based on the assumptions of their non-sequence-dependent formation and high error rates. However, taxonomic composition differed by removal of reads with Ns. We determined whether Ns from pyroseq...

Purpose: The objective of this study was to prepare Propranolol Hydrochloride controlled release matrix tablets and to investigate the effect of the polymer blends and the polymer concentration on drug release. Method: Propranolol Hydrochloride controlled release matrix tablets were prepared by direct compression technique. Hydroxypropylmethylcellulose K15M (HPMC K15M) and Carbopol 934P were us...

The aim of this study was to develop a nanostructured lipid carrier (NLC)-based hydrogel and study its potential for the topical delivery of 5-fluorouracil (5-FU). Precirol® ATO 5 (glyceryl palmitostearate) and Labrasol® were selected as the solid and liquid lipid phases, respectively. Poloxamer 188 and Solutol® HS15 (polyoxyl-15-hydroxystearate) were selected as surfactants. The developed lipi...

the influence of various polymers on the release rate of lithium carbonate from matrix-type tablets was investigated in an attempt to formulate a sustained release solid dosage form. for this purpose, tablets containing 450 mg of lithium carbonate along with various amounts of carbopol 934p, 971p, 974p, pemulen and eudragit rlpo as retarding agents and inactive ingredients (e.g. pvp, avicel or ...

significant effect on bioadhesive strength and in vitro drug release. It was found that carbopol gives higher bioadhesive strength than HPC. Comparatively HPC controls the drug release greater than carbopol. The optimized formulation follows non-Fickian release mechanism. The FT-IR and DTA studies indicate no physico-chemical interaction. Stability studies revealed that optimized formulation wa...

A series of mucoadhesive disks with celecoxib as a model drug of very low aqueous solubility were prepared and characterized. Two polymers of polyaspartamide type, poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)] (PHEA, 1) and its thiolated analogue poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)]-poly[alpha,beta-(N-2-thioethyl-DL-aspartamide)] copolymer (PHTA, 2a,b), and two commercially a...

A long-term oral administration of NSAID and DMARD on rheumatoid arthritis (RA) treatment may cause gastritis, kidney, cardiovascular disorder. One the alternative therapies that have been investigated is by using herbal medicine such as Curcuma longa Linn. which contains curcumin essential oils. Even though both compounds are quite effective in treating RA, poor aqueous solubility low intestin...