mulation of semisolid bases, generally with a significant influence on their rheological properties. When organic amines are employed as neutralizing agents of carbopols, it is possible to gel many semipolar liquids and mixtures of these liquids with water. Compatibility of the polymer and non-polar solvents depends on the formation of ion pairs with the amine. Although alcohols are useful for ...

in this study, the effects of various hydrophilic (hpmc and carbopol 971) and plastic (ethylcellulose and eudragit rl100) polymers on the release profile of diltiazem hcl from matrix tablets were evaluated in-vitro. for this purpose, tablets containing 60 mg of diltiazem hcl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. tablets prep...

Formulation process is a very complex activity which sometimes implicates taking decisions about parameters or variables to obtain the best results in a high variability or uncertainty context. Therefore, robust optimization tools can be very useful for obtaining high quality formulations. This paper proposes the optimization of different responses through the robust Taguchi method. Each respon...

The objectives of this study were to compare dissolution profiles of a verapamil (VRP) formulation manufactured inhouse and Isoptin SR using USP Apparatus 2 and 3 and to elucidate drug release kinetics of these dosage forms. Eudragit NE 30D (ethyl acrylate–methyl methacrylate copolymer in a 2:1 ratio) aqueous dispersion was used as a granulating binder for the manufacture of VRP mini-matrix sus...

Antioksidan merupakan suatu senyawa yang berperan penting dalam mekanisme pertahanan tubuh melawan radikal bebas yaitu menghambat reaksi oksidatif. Salah satu bahan alam memiliki aktivitas antioksidan biji kopi robusta. Biji robusta diketahui mengandung polifenol sebagai antioksidan. Nanooemulgel sediaan gel diinkorporasikan basis dan partikel berukuran nano. Penelitian ini bertujuan untuk 1) m...

The objective of this investigation was to explore the effects of drug solubility on the evolution of matrix dimensions and gel layer's during drug release and investigate the relationship between these effects and the mechanism and the rate of drug release. Two hydrophilic swellable polymers Polyox (POL) and cross-linked Carbopol (CARB) were employed as carriers. Caffeine (CAF) and theophyllin...

Ketoconazole is an imidazole antifungal agent. It has a wide antifungal spectrum and possesses some antibacterial activity. In inappropriate formulations, especially in aqueous media, ketoconazole molecules may be unsteady. The stability of ketoconazole in aqueous media was assessed as a function of pH, antioxidant and ketoconazole concentrations. It was found that ketoconazole was least stable...