نتایج جستجو برای: carboplatin
تعداد نتایج: 5609 فیلتر نتایج به سال:
INTRODUCTION International guidelines are ambivalent regarding the recommendations for the management of clinical stage 1 (CS1) seminoma. PATIENTS AND METHODS During 2008-2013, 1,050 patients with seminoma CS1 were prospectively registered with regard to assessing management modality (radiotherapy, carboplatin, surveillance). Associations with tumor size, rete testis invasion, age, year of di...
Background and Aim: Although combined "Chemotherapy and Focal therapy" is very efficient in the treatment of the low grade forms of Retinoblastoma (Rb), more effective therapeutic measures are required to control the spread of the disease into vitreous and subretinal areas.This study was conducted with the aim of evaluating the effectiveness of chemotherapy combined with perioricular inject...
Carboplatin, also called JM8, was characterized in preclinical testing in the 1970s as being potentially less nephrotoxic and emetogenic that cisplatin. Initial phase I studies were done with dose escalations calculating the dose based on body surface area and defined dose-limiting toxicity at a dose of ∼400 mg/m 2 every 21–28 days as myelosuppression, predominantly thrombo-cytopenia, but which...
Platinum compounds constitute a discrete class of DNA-damaging anticancer drug agents, including cisplatin, carboplatin, and oxaliplatin. The toxicity of such drugs raises the problem of waste detoxification. Diethyl dithiocarbamate (DDTC) is recommended by the World Heath Organization (WHO) for the destruction of cisplatin, but the degradation product has not been structurally characterized. T...
Advanced thymic cancer treated with carboplatin and paclitaxel in a patient undergoing hemodialysis.
A 53-year-old man with an asymptomatic anterior mediastinal tumor undergoing hemodialysis was referred to our institution. He was diagnosed with thymic basaloid carcinoma based on the findings of a chest tomography-guided biopsy and successfully treated with carboplatin (300 mg/m(2)/day) and paclitaxel (200 mg/m(2)/day) on day 1 for six three-week cycles. To our knowledge, this is the first rep...
Drug-induced immune hemolytic anemia (DIIHA) is an uncommon side effect of pharmacologic intervention. A rare mediator of DIIHA, carboplatin is an agent used to treat many pediatric cancers. We describe here, the first case of fatal carboplatin induced DIIHA in a pediatric patient and a brief review of the literature. Our patient developed acute onset of multi-organ failure with evidence of com...
OBJECTIVES Adjuvant radiotherapy produces excellent disease-free rates in clinical Stage I seminoma. However, concern is growing about side effects and late hazards of this treatment. Carboplatin has been suggested to supplant radiotherapy. To date, there is little experience with this drug in the adjuvant treatment of seminoma. In particular, it is unclear whether one or two courses should be ...
PURPOSE A novel regimen designed to maximize antileukemia activity of carboplatin through inhibiting repair of platinum-DNA adducts was conducted in poor prognosis, acute leukemia patients. EXPERIMENTAL DESIGN Patients received fludarabine (10 to 15 mg/m(2) x 5 days), carboplatin (area under the curve 10 to 12 by continuous infusion over 5 days), followed by escalated doses of topotecan infus...
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