This paper presents an architecture called PeSoV using new emerging technologies to increase the security, reliability and connectivity of motorized vehicles. Many people die because of car accidents caused by lack of attention and imprudence of car drivers. Some technologies like the standard IEEE 1609, Zigbee and a network of ranging sensors can be used as tools to help the driver to avoid ac...

BACKGROUND Adoptive transfer of chimeric antigen receptor (CAR)-modified T cells appears to be a promising immunotherapeutic strategy. CAR combines the specificity of antibody and cytotoxicity of cytotoxic T lymphocytes, enhancing T cells' ability to specifically target antigens and to effectively kill cancer cells. Recent efforts have been made to integrate the costimulatory signals in the CAR...

In this paper I consider just how neglected the car has been in contemporary social analyses. Yet it is the most important example of a global technology. I try to rectify this neglect by considering some of the ways in which we can think of people inhabiting the car and more generally inhabiting the system of automobility. The car combines exceptional flexibility and coercion. I consider the n...

The chimeric antigen receptor T (CAR-T) cell therapy is a newly developed adoptive antitumor treatment. Theoretically, CAR-T cells can specifically localize and eliminate tumor cells by interacting with the tumor-associated antigens (TAAs) expressing on tumor cell surface. Current studies demonstrated that various TAAs could act as target antigens for CAR-T cells, for instance, the type III var...

The Ca2+-sensing receptor (CaR) is a pleiotropic, type III G protein-coupled receptor (GPCR) that associates functionally with the cytoskeletal protein filamin. To investigate the effect of CaR signaling on the cytoskeleton, human embryonic kidney (HEK)-293 cells stably transfected with CaR (CaR-HEK) were incubated with CaR agonists in serum-free medium for up to 3 h. Addition of the calcimimet...

Adoptive T-cell therapy with anti-CD19 chimeric antigen receptor (CAR)-expressing T cells is a new approach for treating advanced B-cell malignancies. To evaluate anti-CD19-CAR-transduced T cells in a murine model of adoptive T-cell therapy, we developed a CAR that specifically recognized murine CD19. We used T cells that were retrovirally transduced with this CAR to treat mice bearing a syngen...

The main aim of this project is to offer advance security system in car, which consist of a face detection system, a GPS module, a GSM module and a control platform. The system is mainly used to identify the car and the thief who theft the car. FDS (Face Detection System) is used to detect the face of the driver and compare it with the port folio. The GSM plays an important role in this system....

Public transport is often perceived to be a poor alternative for car use. This paper describes who may be open to use public transport more often, and how people might be persuaded to use it. A computerised questionnaire study was conducted among 1,803 Dutch respondents in May 2001. Results revealed that especially fervent car users disliked public transport. For them, the car outperformed publ...

Impairment of drug disposition in the liver during inflammation has been attributed to downregulation of gene expression of drugmetabolizing enzymes (DMEs) and drug transporters. Inflammatory responses in the liver are primarily mediated by Toll-like receptors (TLRs). We have recently shown that activation of TLR2 or TLR4 by lipoteichoic acid (LTA) and lipopolysaccharide (LPS), respectively, le...