Studies of group interventions on social relationships among patients with cancer have suggested that such can increase patients' support and help build networks, which are expected to reduce the sense loneliness them. The purpose this study was qualitatively investigate between participation in therapy cancer. Seven participants various types participated were interviewed at a medical institut...

MOTIVATION Gene Essentiality Analysis based on Flux Balance Analysis (FBA-based GEA) is a promising tool for the identification of novel metabolic therapeutic targets in cancer. The reconstruction of cancer-specific metabolic networks, typically based on gene expression data, constitutes a sensible step in this approach. However, to our knowledge, no extensive assessment on the influence of the...

PurposeLow-Dose Computed Tomography (LDCT) is the most common imaging modality for lung cancer diagnosis. The presence of nodules in scans does not necessarily portend cancer, as there an intricate relationship between nodule characteristics and cancer. Therefore, benign-malignant pulmonary classification at early detection a crucial step to improve diagnosis prolong patient survival. aim this ...

Family history is a major risk factor for many types of cancer. Mendelian prediction models translate family histories into cancer predictions, based on knowledge susceptibility genes. These are widely used in clinical practice to help identify high-risk individuals. leverage the entire history, but they rely assumptions about genes that either unrealistic or challenging validate, due low mutat...

In recent years, there have been tremendous efforts to elucidate the complex mechanisms of cancer networks by investigating the interactions of different genetic and epigenetic factors. Mathematical tools can help significantly with overcoming many of these challenges and can facilitate better understanding of the complexities of the corresponding networks. This has lead to the emergence of the...

background : gastric cancer is a common and lethal disease throughout the world. in iran with 7300 new cases annually, it is the first cause of cancer related death in both sexes. regarding the high incidence (10.5/100000 individuals) of gastric can­cer and priority of prevalence index in cancer management, in this study we tried to determine 1, 2-3 and 4-5 year point preva­lence of the disease...

this paper aims to assess the quality and accuracy aster dems and the arcgis alogorthms used for hydrologic analyses. to this end, first the plan of drainage networks in the region was extracted from aerial photographs and high resolution satellite images and was set as the real ground. in the next step, using the hydrology tool in arcgis software, raster networks of the region for the whole ca...

Cellular interactions can be modeled as complex dynamical systems represented by weighted graphs. The functionality of such networks, including measures of robustness, reliability, performance, and efficiency, are intrinsically tied to the topology and geometry of the underlying graph. Utilizing recently proposed geometric notions of curvature on weighted graphs, we investigate the features of ...

The aim of this study was to explain the pathogenesis and deterioration process of breast cancer. Breast cancer expression profile data GSE27567 was downloaded from the Gene Expression Omnibus (GEO) database, and breast cancer-related genes were extracted from databases, including Cancer-Resource and Online Mendelian Inheritance In Man (OMIM). Next, h17 transcription factor data were obtained f...

Hepatocellular carcinoma (HCC) is a major liver tumor (~80%), besides hepatoblastomas, angiosarcomas, and cholangiocarcinomas. In this study, we used a systems biology approach to construct protein-protein interaction networks (PPINs) for early-stage and late-stage liver cancer. By comparing the networks of these two stages, we found that the two networks showed some common mechanisms and some ...