ABSTRAK Kematian ibu di Provinsi Jawa Tengah tahun 2019 mengalami penurunan dibandingkan 2018, dengan AKI sebesar 76,93/100.000 kelahiran hidup sebanyak 416 kasus. Laserasi perineum merupakan salah satu penyebab perdarahan postpartum. Berdasarkan data yang diperoleh dari Puskesmas Margasari terdapat 232 (30%) total persalinan 775 kasus laserasi selama 2019. Tujuan penelitian ini adalah untuk me...

A comparative pharmacokinetic study was performed for the optical isomers of grepafloxacin (GPFX), an asymmetric quinolone antibiotic. At steady state in rats receiving a constant infusion of each epimer, R(+)-GPFX and S(-)-GPFX, no marked difference between epimers was observed in plasma concentrations or in biliary and urinary excretion rates. The 3-glucuronides of GPFX are diastereomers. The...

We have previously shown that the multi-drug resistance protein (MRP) mediates the ATP-dependent membrane transport of glutathione S-conjugates and additional amphiphilic organic anions. In the present study we demonstrate the expression of MRP in hepatocytes where it functions in hepatobiliary excretion. Analysis by reverse transcription-PCR of human and normal rat liver mRNA resulted in two e...

Background. The local effect of coronary angioplasty is evaluated on the basis of postangioplasty angiograms. Smooth-walled dilation is considered to represent minimal or no injury, whereas intraluminal haziness corresponds with wall laceration. This study correlates the preangioplasty and postangioplasty angiograms with the histopathology of the target sites. Methods and Results. The study inc...

Nose Lateral osteotomy is known as a major constituent of nose plastic surgery to correct nasal bone deformity and reducing nasal bone width. Different methods of osteotomy have been introduced so far that are categorized into two common internal and external methods. The surgeon has little control on this phase of nose plastic surgery. Several complications have been mentioned for Lateral oste...