نتایج جستجو برای: calpain

تعداد نتایج: 5210  

2012
R. Renjini N. Gayathri A. Nalini M.M. Srinivas Bharath

BACKGROUND & OBJECTIVES Calpain-3, a Ca [2]+ -dependent protease has been implicated in the pathology of neuromuscular disorders (NMDs). The current study aimed to analyze calpain-3 expression in cases diagnosed as muscular dystrophy from the Indian population. METHODS Calpain-3 Western blot analysis in muscle biopsies of immunohistochemically confirmed cases of Duchenne muscular dystrophy (D...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2015
Gerald S Supinski Alexander P Alimov Lin Wang Xiao-Hong Song Leigh A Callahan

Calpain contributes to infection-induced diaphragm dysfunction but the upstream mechanism(s) responsible for calpain activation are poorly understood. It is known, however, that cytokines activate neutral sphingomyelinase (nSMase) and nSMase has downstream effects with the potential to increase calpain activity. We tested the hypothesis that infection-induced skeletal muscle calpain activation ...

Journal: :the iranian journal of pharmaceutical research 0
ines skandrani faculty of dental medecine monastir ludovik leloup inserm umr 911 – cro2 (centre de recherche en oncologie biologique et oncopharmacologie) faculté de pharmacie – 27 bd jean moulin – cs 30064 - 13385 marseille cedex 05 – france herve kovacic inserm umr 911 – cro2 (centre de recherche en oncologie biologique et oncopharmacologie) faculté de pharmacie – 27 bd jean moulin – cs 30064 - 13385 marseille cedex 05 – france marie-geneviève dijoux-franca laboratory of pharmacognosy lyon, france kamel ghedira faculty of pharmacy tunisia leila chekira faculty of pharmacy tunisia

in this study, we investigate the potential of moricandia arvensis methanol leaf extract (meohl) on calpain activity, melanin biosynthesis and dna mutagenicity. cytotoxic effect and measurement of reactive oxygen species (ros) induced by lucigenin in colorectal cells (be) were also determined. in addition the chemical analysis of the extract was also studied and the chemical profile illustrates...

Journal: :Cardiovascular research 2013
Yanpeng Wang Dong Zheng Meng Wei Jian Ma Yong Yu Ruizhen Chen James C Lacefield Huaxi Xu Tianqing Peng

AIMS Doxorubicin causes damage to the heart, which may present as cardiomyopathy. However, the mechanisms by which doxorubicin induces cardiotoxicity remain not fully understood and no effective prevention for doxorubicin cardiomyopathy is available. Calpains, a family of calcium-dependent thiol-proteases, have been implicated in cardiovascular diseases. Their activities are tightly controlled ...

Journal: :The Journal of biological chemistry 2003
Jonathan Rios-Doria Kathleen C Day Rainer Kuefer Michael G Rashid Arul M Chinnaiyan Mark A Rubin Mark L Day

The E-cadherin protein mediates Ca(2+)-dependent interepithelial adhesion. Association of E-cadherin with the catenin family of proteins is critical for the maintenance of a functional adhesive complex. We have identified a novel truncated E-cadherin species of 100-kDa (E-cad(100)) in prostate and mammary epithelial cells. E-cad(100) was generated by treatment of cells with ionomycin or TPA. Ce...

Journal: :Circulation 2011
Takuro Miyazaki Yoshitaka Taketomi Masafumi Takimoto Xiao-Feng Lei Shigeko Arita Joo-ri Kim-Kaneyama Satoru Arata Hisayuki Ohata Hidekazu Ota Makoto Murakami Akira Miyazaki

BACKGROUND Although dysfunction of VE-cadherin-mediated adherence junctions in vascular endothelial cells (ECs) is thought to be one of the initial steps of atherosclerosis, little is known regarding how VE-cadherin is disrupted during atherogenic development. This study focused on the role of calpain, an intracellular cysteine protease, in the proteolytic disorganization of VE-cadherin and sub...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004
Ashakumary Lakshmikuttyamma Ponniah Selvakumar Rani Kanthan Selliah Chandra Kanthan Rajendra K Sharma

BACKGROUND Calpains represent a well-conserved family of Ca2+ -dependent proteolytic enzymes. Recently, the importance of calpain in the metastatic process has received great attention. To investigate whether m-calpain contributes to the pathogenesis of colorectal cancer, we investigated the expression of m-calpain and its inhibitors, calpastatin and high-molecular-weight calmodulin-binding pro...

Journal: :Cardiovascular research 2000
Z Papp J van der Velden G J Stienen

OBJECTIVE The involvement of Calpain-I mediated proteolysis has been implicated in myofibrillar dysfunction of reperfused myocardium following ischemia (stunning). This study addresses the question whether ultrastructural alterations might be responsible for the depressed contractility. METHODS Mechanical properties and protein composition of isolated myocytes after Calpain-I exposure (1.25 U...

2015
Tetsuya Ookura Eiki Koyama Anne Hansen John H. Teeter Yukio Kawamura Joseph G. Brand

The calpains, calcium-activated neutral proteases, play important roles in calcium-regulated intra-cellular signal transduction cascades. Here we report the isolation and initial characterization of a cDNA encoding a calpain 9, digestive tract specific calpain, from catfish taste epithelium. This calpain 9 (Ip-CAPN9a) shares 61% identity with human calpain 9. Phylogenetic analysis provides evid...

Journal: :Tissue & cell 2004
T C Chung Y C Liang J Y Yeh B R Ou

The objectives were to investigate the function of the small subunit in the calpain system by expression of the autolytic form of this subunit in L8 myoblasts. Rat post-autolysis small subunit (21 kDa) cDNA expression plasmid was transfected into L8 myoblasts and selected by G418 containing medium. The concentrations of cytosolic micro-calpain in transfected cells, SS2 and SS3, were found to be...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید