. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . doi:10.1093/ehjci/jeu231 Online publish-ahead-of-pr...

OBJECTIVE In type 2 diabetes mellitus (T2DM), it remains unclear whether coronary artery calcium (CAC) provides additional information about cardiovascular disease (CVD) mortality beyond the Framingham Risk Score (FRS) factors. RESEARCH DESIGN AND METHODS A total of 1,123 T2DM participants, ages 34-86 years, in the Diabetes Heart Study followed up for an average of 7.4 years were separated us...

False-negative results of coronary artery calcium score (CACS) are common due to small calcified lesions being missed using a 3-mm slice thickness, a threshold of 130 Hounsfield units (HU) and a minimum area of 1 mm(2) for defining a calcified plaque. In contrast, false-positive results of CACS, as verified by a lack of coronary artery calcifications in computed tomography coronary angiogram (C...

UNLABELLED Observational studies have linked hypocalcemia with adverse clinical outcome in critically ill patients. However, calcium supplementation has never been formally investigated for its beneficial effect in critically ill patients. To investigate whether calcium supplementation can improve 28-day survival in adult critically ill patients. Secondary analysis of a large clinical database ...

The Electron Beam CT (EBT) Coronary Calcium Score (CCS) is an independent predictor of coronary events and adds incremental information to standard risk factors. How to use this information was uncertain. To assist our referring physicians in utilizing this test, a web based calculator was created that combines the Framingham score risk with the EBT CCS risk to obtain a new risk for cardiac eve...

C the Agatston criteria 1 are widely applied for defining the quantity of coronary calcium (“Agatston score”). To interpret the clinical significance of a given Agatston score, it is essential to consider the age and gender of the individual patient. Agatston score percentile values have been established on the basis of measurements from electron beam computed tomography (EBCT). Because of the ...

Esther Lutgens1,2; Tim Leiner3; Christian Weber1,4 1Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian’s University (LMU), Munich, Germany; 2Department of Medical Biochemistry, Academic Medical Center Amsterdam, University of Amsterdam, the Netherlands; 3Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands; 4Department of Pathology, Cardiovascular ...

The past 2 decades have witnessed great progress in the treatment of advanced cardiovascular disease. Mortality of revascularization is close to or below 1% among cardiovascular centers of excellence, time for reperfusion has been dramatically shortened in acute coronary syndromes, and a larger segment of the population has gained access to advanced cardiovascular care. Yet the burden of cardio...