نتایج جستجو برای: calcium promoter

تعداد نتایج: 255296  

Ahmad Mohamad Zaki, Amel Sobhy El Sedfy, Heba Gaber El-Sheredy, Ola Hussein Elgaddar, Sara Ahmed Aglan,

Background: ATP-binding cassette membrane transporter G2 (ABCG2) gene is one of transporter family and well characterized for their association with chemoresistance. Promoter methylation is a mechanism for regulation of gene expression. O6-Methyl guanine DNA methyl transferase (MGMT) gene plays a fundamental role in DNA repair. MGMT has the ability to remove alkyl adducts from DNA at the O6 pos...

Journal: :modares journal of medical sciences: pathobiology 2013
shahla mohammad ganji elham samei seyed ahmad hashemi amir rezagholizadeh anooshirvan kazemnejad

objective: e-cadherin is widely down-regulated and tightly associated with tumor invasion and metastasis in multiple human cancer types. recent studies have shown that aberrant methylation of the e-cadherin gene promoter contributes to its silencing. however, information regarding epigenetic inactivation of e-cadherin in colorectal cancer is insufficient. herein, we correlate association of the...

2013
Kazi Md. Kamrul Huda Mst. Sufara Akhter Banu Krishna Mohan Pathi Narendra Tuteja

BACKGROUND Plasma membrane Ca(2+)ATPase is a transport protein in the plasma membrane of cells and helps in removal of calcium (Ca(2+)) from the cell, hence regulating Ca(2+) level within cells. Though plant Ca(2+)ATPases have been shown to be involved in plant stress responses but their promoter regions have not been well studied. RESULTS The 1478 bp promoter sequence of rice plasma membrane...

Journal: :Glia 2013
Kai Gao Chen Ran Wang Feng Jiang Ann Yuen Kwan Wong Na Su Jiao Hua Jiang Rui Chao Chai Greg Vatcher Junlin Teng Jianguo Chen Yu-Wu Jiang Albert Cheung Hoi Yu

Astrocyte activation is a hallmark of central nervous system injuries resulting in glial scar formation (astrogliosis). The activation of astrocytes involves metabolic and morphological changes with complex underlying mechanisms, which should be defined to provide targets for astrogliosis intervention. Astrogliosis is usually accompanied by an upregulation of glial fibrillary acidic protein (GF...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Mitsuhiro Morita Chitose Higuchi Takanori Moto Nagisa Kozuka Jinichi Susuki Rurika Itofusa Jiro Yamashita Yoshihisa Kudo

In response to neurotransmitters, astrocytes show various types of calcium increase (transient, oscillatory, and complex), the physiological significance of which is still controversial. To explore this variability, we examined factors affecting the calcium increase pattern in cultured astrocytes and investigated the consequences of the astrocytic calcium response in slice preparations. We foun...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
L Zirpel M A Janowiak C A Veltri T N Parks

Although dependence on afferent synaptic activity has been shown for central neurons in every sensory system, the mechanisms of afferent maintenance of target sensory neurons are not understood. Neurons in the cochlear nucleus (CN) require afferent activity for maintenance and survival. One of the earliest changes seen after activity deprivation is an increase in intracellular calcium that lead...

Journal: :Journal of health sciences and medicine 2023

Objective: In the last two decades, research on epigenetic mechanisms has expanded dramatically. Recent studies demonstrated that regulate epilepsy and epileptogenic pathologies. this study, we aimed to investigate changes in promoter methylation status of voltage-gated T-type calcium channel alpha 1 subunit G (CACNA1G) gene total histone deacetylase activity Wistar Albino Glaxo/Rijswijk (WAG/R...

2014
Jennifer H. Hou Joel M. Kralj Adam D. Douglass Florian Engert Adam E. Cohen

The cardiac action potential (AP) and the consequent cytosolic Ca(2+) transient are key indicators of cardiac function. Natural developmental processes, as well as many drugs and pathologies change the waveform, propagation, or variability (between cells or over time) of these parameters. Here we apply a genetically encoded dual-function calcium and voltage reporter (CaViar) to study the develo...

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