Calciphylaxis is a relatively rare disorder associated with calcification of smalland medium-sized blood vessels, progressive ischemic skin necrosis, and ulcerations. This situation is a potentially life-threatening condition seen in patients with endstage renal disease (ESRD). A 64-year-old man with ESRD on dialysis for 6 years was admitted to our clinic with severe pain and partial necrosis o...

Results: Of the 31 patients, all presented with 1 or multiple painful necrotic skin ulcers on the laterodorsal part of the leg, with bilateral involvement in 16 of 31 cases (52%), and 16 were referred with suspected pyoderma gangrenosum. All patients had arterial hypertension, and 18 (58%) had diabetes. All patients had subcutaneous stenotic arteriolosclerosis on histologic analysis, with media...

Calciphylaxis, or calcific uremic arteriolopathy, is a rare vascular disease that is seen in end stage renal disease and renal transplant patients; however, there are cases reported in literature with normal renal function but little systematic information is available on calciphylaxisfrom nonuremic causes. This article reviews the etio-pathogenesis, clinical features, laboratory abnormalities,...