The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.

Abstract Objectives Cancer chemotherapeutic treatments come with many adverse effects. Anticancer studies natural products have been carried out to minimize these issues. This study aimed evaluate the anticancer potential of endemic Phlomis brevibracteata Turrill against four different Hepatocellular Carcinoma (HCC) cell lines and find new candidates for cancer treatment. Methods The chemical c...

The accurate quantification of phenolic compounds (PCs) in foods has become mandatory for a reliable estimation PCs dietary intake. However, the extraction step these molecules from food matrix is challenging and complex task. To manage current lack an official or generally accepted procedure recovery phenolics, application statistical mathematical tools, such as response surface methodology (R...

Abstract We have purified a novel caffeoylquinic acid named 3,4-di- O -caffeoylquinic isobutyl ester from the flower buds of Lonicera japonica Thunb., Caprifoliaceae. However, biological function is still unknown. Here, we found that effectively inhibited proliferation and migration hepatocellular carcinoma cells, it displayed less toxicity to normal liver cell line. Mechanistic studies showed ...

BACKGROUND Traditional antibiotics are increasingly suffering from the emergence of multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to control microbial infections being investigated as potential alternative treatments. One plausible antimicrobial alternative could be the combination of conventional antimicrobial agents/antibiotics with small molecules wh...

Enzymatic browning negatively impacts product quality and shelf-life of packaged fresh-cut lettuce. Metabolite profiles lettuce are affected by the process. The purpose this study was to identify metabolomic marker compounds predict browning, which could be applied discern accessions suited for commercial production industrial breeding programs. Romaine with different susceptibilities were eval...