Diabetic peripheral neuropathy (DPN) is one of the most common diabetic complications. Mechanisms underlying nerve damage and sensory loss following metabolic dysfunction remain large unclear. Recently, hyperglycemia-induced mitochondrial dysfunction and the generation of ROS have gained attention as possible mechanisms of organ damage in diabetes. Hypoxia-inducible factor 1 (HIF1) is a key tr...

Hypoxia occurs in cancer, prolonged exercise, and long-term ischemia with durations of several hours or more, and the hypoxia-inducible factor 1 (HIF1) pathway response to these conditions differs from responses to transient hypoxia. We used computational modeling, validated by experiments, to gain a quantitative, temporal understanding of the mechanisms driving HIF1 response. To test the hypot...

Assessment of left ventriculr function following coronary bypass surgery: a non-invasive study. In a series of 15 patients with ischaemic heart disease, systolic time intervals (STI) were measured before, and at one week, three months, and six months following coronary vein-graft surgery. Preoperatively, the left ventricular ejection time (LVET) was abnormally short in seven patients, while the...

There has been an increasing trend in the production and consumption of local and imported fruit juices in Iran. The presence of impurities and foreign matter in finished products for human consumption is of great concern because they present health hazards when they exceed beneficial limits. The manufacture of juices requires special attention in terms of purity and the sources of water and it...

After 150 years of industrial activity, significant pollution of surface soils in private gardens and locally produced vegetables with lead, cadmium, and arsenic has recently been observed in Viviez (Southern France). A public health intervention was conducted in 2008 to identify individual health risks of Viviez inhabitants and to analyze their environmental exposure to these pollutants. Child...

The aim of the present study was to investigate the effects of long-term grape juice concentrate (GJC) consumption, in two dosages, on the reproductive parameters of cadmium-exposed male rats. The effects of the concentrate on body mass gain, plasma testosterone levels, reproductive organ weights, daily sperm production, sperm morphology, testis histopathological and histomorphometrical paramet...

we determined the concentrations of lead and cadmium in edible parts of colocasiaesculenta,amaranthusspp. and ipomoea batata cultivated on farms in industrially polluted sections of nyabugogomarsh (kigali, rwanda) and quantified metal intake by consumers of these crops. we report that metalconcentrations in crops were within eu limits. the highest metal concentrations were found in amaranthussp...

Whole body oxygen consumption and some hemolymph parameters such as pH, partial pressure of gases, level of ions and lactate were measured in the estuarine crab Chasmagnathus granulata after both acute (96 h) and chronic (2 weeks) exposure to cadmium at concentrations ranging from 0.4 to 6.3 mg/l. In all instances, the crabs developed hemolymph acidosis, but no respiratory (increased PCO2) or l...

Studies of the cardiac output of normal individuals during muscular exercise have been made by several investigators (l-5). Systemic blood pressure has likewise been measured during exercise, making possible the calculation of peripheral resistance and the work of the left ventricle. Until recently (5), such information was not available in the case of the right ventricle because pulmonary arte...

OBJECTIVES Using proton magnetic resonance spectroscopy, we investigated cerebral metabolism and its determinants in congestive heart failure (CHF), and the effects of cardiac transplantation on these measurements. BACKGROUND Few data are available about cerebral metabolism in CHF. METHODS Fifty patients with CHF (ejection fraction < or = 35%) and 20 healthy volunteers were included for thi...