We performed a meta-analysis of 4 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 3 loci newly associated with CAD at P < 5 × 0−8 and confirmed the association of 0 of 2 previously rep...

Introduction: Coronary Artery Disease (CAD) continues to be the leading cause of morbidity and mortality in developed countries. It is of particular concern in the aviation industry since it can result in sudden incapacitation. Moreover, it is the leading cause of pilot grounding. The aim of this study was to determine the prevalence of modifiable CAD risk factors among Gulf air pilots in Bahra...

OBJECTIVE Epicardial adipose tissue (EAT) is suggested to correlate with metabolic risk factors and to promote plaque development in the coronary arteries. We sought to determine whether EAT thickness was associated or not with the presence and extent of angiographic coronary artery disease (CAD). METHODS We measured epicardial fat thickness by computed tomography and assessed the presence an...

BACKGROUND Coronary artery disease (CAD) is a leading cause of mortality, morbidity, and disability with high health care cost in Iran. It accounts for nearly 50 percent of all deaths per year. Yet little is known about CAD and CAD risk factors in the Iranian population. We aimed to assess the prevalence of different CAD risk factors in an Iranian population. METHODS A descriptive cross secti...

BACKGROUND Diverse ethnic groups may differ regarding the risk factors and severity of coronary artery disease (CAD). This study sought to assess the association between ethnicity and CAD risk and severity in six major Iranian ethnic groups. METHODS In this study, 20,165 documented coronary artery disease patients who underwent coronary angiography at a tertiary referral heart center were rec...

CONTEXT Individual contributions of obesity and physical fitness (physical activity and functional capacity) to risk of coronary heart disease in women remain unclear. OBJECTIVE To investigate the relationships of measures of obesity (body mass index [BMI], waist circumference, waist-hip ratio, and waist-height ratio) and physical fitness (self-reported Duke Activity Status Index [DASI] and P...

Coronary artery disease (CAD) risk factor profiles change over time. The death rate from coronary disease has been decreasing mainly due to changes in levels of risk factors, and improvement in CAD treatments. However, there are risk factors, whose prevalence is increasing, such as diabetes and obesity. When the risk factor profile changes, we can assume that gene profiles and epigenetics also ...

OBJECTIVE To assess the association between secretory phospholipase A2 (sPLA2) activity, which encompasses several types of sPLA2, and cardiovascular disease (CAD) in healthy individuals. METHODS AND RESULTS We investigated this association in a nested case-control study among the 25,663 participants in EPIC-Norfolk cohort. Cases (n=991) were subjects in whom CAD developed during the 6 years ...

The study aimed to construct a risk prediction model for coronary artery disease (CAD) based on competing risk model among the elderly in Beijing and develop a user-friendly CAD risk score tool. We used competing risk model to evaluate the risk of developing a first CAD event. On the basis of the risk factors that were included in the competing risk model, we constructed the CAD risk prediction...