نتایج جستجو برای: caco 2 cell

تعداد نتایج: 3839619  

Journal: :Journal of pharmaceutical sciences 2004
Chantal Masungi Caroline Borremans Bart Willems Jurgen Mensch Alex Van Dijck Patrick Augustijns Marcus E Brewster Mark Noppe

A simple, reliable, and user friendly system was established to cultivate Caco-2 cell monolayer for epithelial transport studies. After an initial growth period of 1 week in a CO(2) incubator, Caco-2 cells were cultivated in an automated continuous perfusion system (Minucells and Minutissue, Germany). Medium was constantly renewed at the apical and basal side of the monolayers, which resulted i...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Grigorios Fotopoulos Alexandre Harari Pierre Michetti Didier Trono Giuseppe Pantaleo Jean-Pierre Kraehenbuhl

Human colon carcinoma Caco-2 cell monolayers undergo conversion into cells that share morphological and functional features of M cells when allowed to interact with B lymphocytes. A lymphotropic (X4) HIV-1 strain crosses M cell monolayers and infects underlying CD4(+) target cells. Transport requires both lactosyl cerebroside and CXCR4 receptors, which are expressed on the apical surface of Cac...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2001
E Störmer M D Perloff L L von Moltke D J Greenblatt

This study investigated the effects of racemic methadone (MET) on P-glycoprotein (P-gp) activity in cell culture. MET showed no differential rates of passage between the basolateral to apical (B to A) and apical to basolateral (A to B) direction across Caco-2 cell monolayers in a transwell system. MET transport in either direction was not importantly influenced by the P-gp inhibitor verapamil. ...

Journal: :The American journal of clinical nutrition 2007
Jeannemarie M Beiseigel Janet R Hunt Raymond P Glahn Ross M Welch Abebe Menkir Bussie B Maziya-Dixon

BACKGROUND An in vitro digestion and Caco-2 cell model may predict iron bioavailability to humans; however, direct comparisons are lacking. OBJECTIVE The objective was to test the differences in iron bioavailability between 2 maize varieties and 2 bean varieties (white beans and colored beans) by comparing human, Caco-2, and algorithm results. DESIGN Two randomized, 2 x 2 factorial experime...

2012
Byong Kwon Yoo Murali Krishna Yanda Yi Ran Chris Yun

Yoo BK, Yanda MK, No YR, Yun CC. Human intestinal epithelial cell line SK-CO15 is a new model system to study Na /H exchanger 3. Am J Physiol Gastrointest Liver Physiol 303: G180–G188, 2012. First published May 2, 2012; doi:10.1152/ajpgi.00069.2012.—The Caco-2 cell line represents absorptive polarized intestinal epithelial cells that express multiple forms of Na /H exchanger (NHE) in their plas...

Journal: :Nutrition Journal 2005
Jeanelle Boyer Dan Brown Rui Hai Liu

BACKGROUND Quercetin and quercetin glycosides are widely consumed flavonoids found in many fruits and vegetables. These compounds have a wide range of potential health benefits, and understanding the bioavailability of flavonoids from foods is becoming increasingly important. METHODS This study combined an in vitro digestion, a lactase treatment and the Caco-2 cell model to examine quercetin ...

Journal: :Gastroenterology 2003
Alessia Ligresti Tiziana Bisogno Isabel Matias Luciano De Petrocellis Maria Grazia Cascio Vittorio Cosenza Giuseppe D'argenio Giuseppe Scaglione Maurizio Bifulco Italo Sorrentini Vincenzo Di Marzo

BACKGROUND & AIMS The endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG) inhibit cancer cell proliferation by acting at cannabinoid receptors (CBRs). We studied (1). the levels of endocannabinoids, cannabinoid CB(1) and CB(2) receptors, and fatty acid amide hydrolase (FAAH, which catalyzes endocannabinoid hydrolysis) in colorectal carcinomas (CRC), adenomatous polyps, and neighboring...

2011
Katayoun Derakhshandeh Gunther Hochhaus Simin Dadashzadeh

The uptake and transport of 9-nitrocamptothecin (9-NC), a potent anticancer agent, across Caco-2 cell monolayers was studied as a free and PLGA nanoparticle loaded drug. Different sizes (110 to 950 nm) of 9-nitrocamptothecin nanoparticles using poly (lactic-glycolic acid) were prepared by via the nanoprecipitation method. The transport of nanoparticles across the Caco-2 cell monolayer as a func...

Journal: :Molecular medicine reports 2013
Hai-Yue Jiang Feng Wang Hai-Min Chen Xiao-Jun Yan

κ-carrageenan (κ-CGN) is an important food additive that has been demonstrated to induce colitis in animal models. In the present study, the effects of κ-CGN were assessed using an in vitro co-culture system that contained intestinal epithelial Caco-2 cells and activated macrophage-like THP-1 cells. The results demonstrated that in single cultures of Caco-2 and THP-1 cells treated with κ-CGN, t...

Journal: :European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2012
Johanna J Salomon Sibylle Endter Gaëlle Tachon Françoise Falson Stephen T Buckley Carsten Ehrhardt

Organic cation/carnitine transporters (OCT/N) mediate uptake of positively charged molecules. Their role in lung epithelium; however, is not well understood. OCT/N expression and activity was studied in cell lines of human alveolar (A549), bronchial (16HBE14o- and Calu-3) and intestinal (Caco-2) epithelium. Protein levels were largely comparable for all OCT/Ns in the respiratory epithelial cell...

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