نتایج جستجو برای: ca2 channel current

تعداد نتایج: 1015700  

Journal: :Journal of neurophysiology 1997
M Margeta-Mitrovic J J Grigg K Koyano Y Nakajima S Nakajima

Inhibition of Ca2+ currents by the excitatory neurotransmitters neurotensin and substance P was investigated in cultured nucleus basalis neurons with the use of the whole cell patch-clamp technique. The whole cell Ca2+ current, elicited from a holding potential of -80 mV by a step pulse to 0 mV and measured at 100 ms, was inhibited 67.9% by neurotensin and 57.6% by substance P. Low-voltage-acti...

Journal: :The Journal of physiology 1987
P Cobbett C D Ingram W T Mason

1. The properties of whole-cell and single-channel Na+ and K+ currents in immunocytochemically identified bovine lactotrophs were studied using the patch-clamp technique. 2. In the whole-cell, current-clamp mode, cells had membrane potentials of -94.7 +/- 6.7 mV and input resistances of 2-17 G omega. Current-induced action potentials were recorded with a threshold around -35 mV and amplitude of...

Journal: :Circulation research 1994
M Kaibara S Mitarai K Yano M Kameyama

The present study investigated the possible involvement of a Na(+)-H+ antiporter in the regulation of L-type Ca2+ channels by angiotensin II (Ang II) in isolated rabbit ventricular cardiac myocytes by using both cell-attached and whole-cell patch-clamp current recording techniques. In cell-attached patch-clamp current recordings, an increase in the open-state probability of the Ca2+ channel (14...

2017
Debebe Gebremedhin David X Zhang Dorothee Weihrauch Nnamdi N Uche David R Harder

The transient receptor potential vallinoid type 4 (TRPV4) is a calcium entry channel known to modulate vascular function by mediating endothelium-dependent vasodilation. The present study investigated if isolated cerebral arterial myocytes of the Fawn Hooded hypertensive (FHH) rat, known to display exaggerated KCa channel current activity and impaired myogenic tone, express TRPV4 channels at th...

Journal: :International journal for parasitology 2006
Michael C Jeziorski Robert M Greenberg

Voltage-gated calcium (Ca2+) channels provide the pathway for Ca2+ influxes that underlie Ca2+ -dependent responses in muscles, nerves and other excitable cells. They are also targets of a wide variety of drugs and toxins. Ca2+ channels are multisubunit protein complexes consisting of a pore-forming alpha(1) subunit and other modulatory subunits, including the beta subunit. Here, we review the ...

Journal: :Journal of neurophysiology 2003
Sherwin C Lee Yuki Hayashida Andrew T Ishida

Spiking in central neurons depends on the availability of inward and outward currents activated by depolarization and on the activation and priming of currents by hyperpolarization. Of these processes, priming by hyperpolarization is the least described. In the case of T-type Ca2+ current availability, the interplay of hyperpolarization and depolarization has been studied most completely in exp...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 1999
Bernard R Hurley Harold G Preiksaitis Stephen M Sims

We examined the properties of K+ channels in smooth muscle cells dissociated from human esophagus using patch-clamp recording in the cell-attached configuration. The predominant channel observed had a conductance of 224 ± 4 pS, and current reversal was dependent on K+ concentration. Channel activity was voltage dependent and increased with elevation of intracellular free Ca2+ concentration ([Ca...

Background & Objective: Verapamil, nifedipine and diltiazem are calcium channel blockers widely used as a variety of cardiovascular ailment in humans. A number of studies have shown that calcium channel blockers have anticonvulsant effect in a range of animal seizure models (but not all animals). The aim of this study was to investigate the effects of verapamil, nifedipine and diltiazem on pe...

Journal: :The Journal of General Physiology 1988
R L Rosenberg P Hess R W Tsien

Planar lipid bilayer recordings were used to study Ca channels from bovine cardiac sarcolemmal membranes. Ca channel activity was recorded in the absence of nucleotides or soluble enzymes, over a range of membrane potentials and ionic conditions that cannot be achieved in intact cells. The dihydropyridine-sensitive L-type Ca channel, studied in the presence of Bay K 8644, was identified by a de...

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