Ca2+ homeostasis is an important factor, which is underlined by the numerous clinical symptoms that involve Ca2+ deficiencies. The overall Ca2+ balance is maintained by the concerted action of Ca2+ absorption in the intestine, reabsorption in the kidney, and exchange from bone, which are all under the control of the calciotropic hormones that are released upon a demand for Ca2+. In the kidney, ...

Objective(s): Thyroid hormones play an essential role in fetal growth and maternal hypo-thyroidism which leads to cardiovascular deficiency in their offspring.  Considering this, we intended to investigate the impact of gestational hypothyroidism on offspring vascular contractibility and possible underlying mechanisms. Materials and Methods: Hypothyroidism was induced in female rats by administ...

apoptosis, a form of programmed cell death that occurs under physiological as well as pathological conditions, is characterized by morphological and biochemical features. while the importance of caspases in apoptosis is established, several noncaspase proteases (ca2+-dependent proteases) such as calpain may play a role in the execution of apoptosis. the calpain family consists of two major isof...

Inositol 1,4,5-trisphosphate (IP3) evokes release of Ca2+ from the endoplasmic reticulum (ER), but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles. Bafilomycin A1, which prevents lysosomal Ca2+ uptake by inhibiting H+ pumping into lysosomes, increased the amplitude of the initial Ca2+ signals evoked by carbachol in human embryonic kidney (HEK) cell...

At fertilization, the sperm initiates development of the mouse egg by inducing a large transient increase in the intracellular Ca2+ concentration ([Ca2+]i), which is followed by repetitive transient increases in [Ca2+]i. To determine how the repetitive Ca2+ transients are produced, thapsigargin, an inhibitor of the endoplasmic reticulum Ca-ATPase, was used to deplete intracellular Ca2+ stores w...

Ca2+ signals in cardiac muscle cells are composed of spatially limited elementary events termed Ca2+ sparks. Several studies have also indicated that Ca2+ signals smaller than Ca2+ sparks can be elicited. These signals have been termed Ca2+ quarks and were proposed to result from the opening of a single Ca2+ release channel of the sarcoplasmic reticulum. We used laser-scanning confocal microsco...

The study determines the major ion chemistry of Teesta River catchment in Eastern Himalayan region and evaluates hydrochemical processes controlling water composition area. Water basin was neutral to alkaline condition. HCO3−, Ca2+, Na+, Mg2+ SO42- were identified as dominant ionic species Ca-Mg-HCO3 facies. Higher contribution (Ca2++Mg2+) HCO3− towards TZ+ TZ−, high ratios (Ca2++Mg2+)/(Na++K+)...

The activity of the cardiac Na+/Ca2+ exchanger is stimulated allosterically by Ca2+, but estimates of the half-maximal activating concentration have varied over a wide range. In Chinese hamster ovary cells expressing the cardiac Na+/Ca2+ exchanger, the time course of exchange-mediated Ca2+ influx showed a pronounced lag period followed by an acceleration of Ca2+ uptake. Lag periods were absent ...

Birger Kollmeier, Michael A. Akeroyd, Stig Arlinger, Ruth A. Bentler, Arthur Boothroyd, Norbert Dillier, Wouter A. Dreschler, Jean-Pierre Gagne, Mark E. Lutman, Jan Wouters and Lena Wong, Letter: Reply to the Comment on International Collegium of Rehabilitative Audiology (ICRA) recommendations for the constructor of multilingual speech test by Akeroyd et al by Cas Smits in INTERNATIONAL JOURNAL...

pathogenesis of atherosclerosis. Biological and biochemical properties of fibroblast growth factors. Implications for the Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 1989 American Heart Association, Inc. All rights reserved. Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Greenville Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.AT...