This paper provides new empirical evidence that bears on the efficacy of unconventional monetary policies when main policy rate is negative. When a negative interest (NIRP) deployed in concert with forward guidance (FG) and quantitative easing (QE), identification impacts these instruments challenging. We propose novel approach seeks to overcome this challenge by combining dense, controlled eve...

In a study of chromosomal enlargement in neoplasms, it had been observed that metaphasic chromosomes of the cells of 6 long-transferred lines of lymphatic leukemia were usually larger in male host mice than in female (12). This sexual difference suggested an investigation of the effect of sex hormones on chromosome size in leukemic and normal lymphocytes. Experiments along several possible line...

A two directional approach, in which asymmetric dihydroxylation and reduction reactions were used to control absolute configuration, was exploited in the preparation of a C(2)-symmetrical dipyranone. The homotopic dihydropyran (DHP) rings of this precursor were differentiated statistically using by a Prevost reaction and further functionalisation. A second Prevost reaction was used to functiona...

Uronate dehydrogenase has been cloned from Pseudomonas syringae pv. tomato strain DC3000, Pseudomonas putida KT2440, and Agrobacterium tumefaciens strain C58. The genes were identified by using a novel complementation assay employing an Escherichia coli mutant incapable of consuming glucuronate as the sole carbon source but capable of growth on glucarate. A shotgun library of P. syringae was sc...

ACUTE lymphatic leukemia, originating in the thymus and frequently involving the spleen, lymph nodes and liver, occurs spontaneously in a large percentage of mice of two inbred strains of independent origin: the AK (and its substrain, AKR) and the C58. GROSS ( 195 1,1961 ) has isolated a virus from strain AK leukemic tissues which, when inoculated into mice of the inbred C3Hf/Bi or C57BR strain...