نتایج جستجو برای: c57bl6

تعداد نتایج: 1088  

2010
Merlin C. Thomas Raelene J. Pickering Despina Tsorotes Audrey Koitka Karen Sheehy Stella Bernardi Barbara Toffoli Thu-Phuc Nguyen-Huu Geoffrey A. Head Yi Fu Jaye Chin-Dusting Mark E. Cooper Chris Tikellis

Rationale: Angiotensin-converting enzyme (ACE)2 opposes the actions of angiotensin (Ang) II by degrading it to Ang 1-7. Objective: Given the important role of Ang II/Ang 1-7 in atherogenesis, we investigated the impact of ACE2 deficiency on the development of atherosclerosis. Methods and Results: C57Bl6, Ace2 knockout (KO), apolipoprotein E (ApoE) KO and ApoE/Ace2 double KO mice were followed u...

2015
Aili Guo Nigel A. Daniels Jean Thuma Kelly D. McCall Ramiro Malgor Frank L. Schwartz

BACKGROUND Clinical studies suggest that short-term insulin treatment in new-onset type 2 diabetes (T2DM) can promote prolonged glycemic control. The purpose of this study was to establish an animal model to examine such a "legacy" effect of early insulin therapy (EIT) in long-term glycemic control in new-onset T2DM. The objective of the study was to investigate the role of diet following onset...

2011
Geert C van Almen Wouter Verhesen Rick E W van Leeuwen Mathijs van de Vrie Casper Eurlings Mark W M Schellings Melissa Swinnen Jack P M Cleutjens Marc A M J van Zandvoort Stephane Heymans Blanche Schroen

To understand the process of cardiac aging, it is of crucial importance to gain insight into the age-related changes in gene expression in the senescent failing heart. Age-related cardiac remodeling is known to be accompanied by changes in extracellular matrix (ECM) gene and protein levels. Small noncoding microRNAs regulate gene expression in cardiac development and disease and have been impli...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2013
Mette Stæhr Pernille B L Hansen Kirsten Madsen Paul M Vanhoutte Rolf M Nüsing Boye L Jensen

Experiments were designed to test the hypothesis that cyclooxygenase-2 (COX-2) activity attenuates the blood pressure increase during high NaCl intake by stimulation of endothelial nitric oxide synthase (eNOS)-mediated NO synthesis in the kidney medulla. COX-2(-/-) (C57BL6) an COX-2(+/+) mice were fed a diet with 0.004% (low salt, LS) or 4% (high salt, HS) NaCl for 18 days. Arterial blood press...

2014
Justin P. Smith Justin K. Achua Tangi R. Summers Patrick J. Ronan Cliff H. Summers

In a newly developed conceptual model of stressful social decision-making, the Stress-Alternatives Model (SAM; used for the 1st time in mice) elicits two types of response: escape or remain submissively. Daily (4d) aggressive social interaction in a neutral arena between a C57BL6/N test mouse and a larger, novel aggressive CD1 mouse, begin after an audible tone (conditioned stimulus; CS). Altho...

Journal: :Advances in medical sciences 2007
K A Kamiński E Oledzka K Białobrzewska M Kozuch W J Musiał M M Winnicka

PURPOSE Prolonged physical training leads to compensatory changes in cardiovascular system. One of the most important of them is cardiac hypertrophy. The knowledge, which factors contribute to cardiomyocyte hypertrophy caused by physical exercise is still incomplete. Interleukin 6 (IL6) secreted by contracting skeletal muscles may affect cardiac hypertrophy and remodeling. The aim of the study ...

Journal: :Circulation research 2010
Merlin C Thomas Raelene J Pickering Despina Tsorotes Audrey Koitka Karen Sheehy Stella Bernardi Barbara Toffoli Thu-Phuc Nguyen-Huu Geoffrey A Head Yi Fu Jaye Chin-Dusting Mark E Cooper Chris Tikellis

RATIONALE Angiotensin-converting enzyme (ACE)2 opposes the actions of angiotensin (Ang) II by degrading it to Ang 1-7. OBJECTIVE Given the important role of Ang II/Ang 1-7 in atherogenesis, we investigated the impact of ACE2 deficiency on the development of atherosclerosis. METHODS AND RESULTS C57Bl6, Ace2 knockout (KO), apolipoprotein E (ApoE) KO and ApoE/Ace2 double KO mice were followed ...

2011
Erik Melén Alvin T Kho Sunita Sharma Roger Gaedigk J Steven Leeder Thomas J Mariani Vincent J Carey Scott T Weiss Kelan G Tantisira

BACKGROUND Little is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only important early in life, but also for later lung function. OBJECTIVE To investigate the role of expression patterns of well-defined asthma susceptibility genes during human and murine lung development. We hypothesized that g...

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