the gene coding claudin (cldn5) is located on 22q11. since the proteins of cldn5 family are a ma-jor component for barrier-forming tight junctions, it may be important to test whether or not the cldn5 locus could be associated with schizophrenia.a total of 150 individuals affected with schizophrenia and 150 healthy persons were recruited. the relation-ship between the three single nucleotide po...

background and objectives: annexin is the common name for genes and proteins that were identified as calcium-dependent phospholipid-binding proteins. recently a more complex set of functions has been recognized for this superfamily of proteins including in vesicle trafficking, cell division, apoptosis, calcium signalling, mineralization, crystal nucleation inside the extracellular organelles-ma...

ône-third of population deal with sleep disorders which might be due to social, economic or medical problems. studies on twins have indicated the role of genetic factors in these disorders. monozygotic twins have a very similar hypnogram. â higher prevalence of some sleep disorders is reported in relatives of the patients with these disorders. genes also affect sleep disorders as well as some o...

aim : the purpose of this study was to assess the incidence of 16bp insertion of intron 3 p53 in gastritis lesion and its correlation with clinicopathological aspects. background : p53 alterations have been implicated in the development of gastric malignancies. patients and methods : 97 gastritis and normal adjacent tissues were investigated for p53 gene analysis using pcr-sequencing of intron3...

background: the pathogenesis of many diseases is correlated to irregularity in vascular endothelial growth factor (vegf) expression. results from several association studies show that variation in the level of vegf expression is related to polymorphic sequences within the vegf gene. additionally, there are many studies showing that some gene polymorphisms significantly influence the pharmacokin...

abstract: background: rabies has been reported in all provinces and cities of iran, although there has been no molecular study regarding different groups and subgroups of rabies virus by phosphoprotein gene. in this study, firstly, 48 and then 85 recent rabies isolates recovered from cases reported throughout iran identified the evolutionary origins by molecular method of phosphoprotein gene re...

background: hypospadias is one of the most common congenital abnormalities in the male which is characterized by altered development of urethra, foreskin and ventral surface of the penis. androgen receptor gene plays a critical role in the development of the male genital system by mediating the androgens effects. objective: in present study, we looked for new variations in androgen receptor pro...

background and objectives: significant progress has been made in treatment of hemophilia. ex-vivo gene therapy is going popular due to the capability of this method in using isogenic cells for genetic manipulation and reintroducing them into same host after proliferation. most gene therapy techniques use viral vectors, which usually harbor a strong and non-specific promoter (e.g. cmv early prom...

background: the availability of testis specific genes will be of help in choosing the most promising biomarkers for the detection of testicular sperm retrieval in patients with non-obstructive azoospermia (noa). testis specific chromodomain protein y 1 (cdy1) is a histone acetyltransferase which concentrates in the round spermatid nucleus, where histone hyperacetylation occurs and causes the re...