In 1916 Jacobs, Heidelberger, and coworkers at the Rockefeller Institute reported the discovery of a new class of synthetic compounds which possessed potent bactelicidal properties. By reacting hexamethylenetetramine with a large variety of substituted benzylor alkyl-halides, nujmerous quaternary salts of this base were obtained. It was observed that most of these salts had pronounced bacterici...

quaternary ammonium compounds (qacs) are employed both as disinfectants for manual processing lines and surfaces in the food industry, and in human medicine area. qacs also cause cell death by protein denaturation . one of the qac is cetyl trimethyl ammonium bromide (ctab) that appears to rapture the cell membrane. the primary site of action of ctab has been suggested to be the lipid components...

BACKGROUND Various drugs have been tried to hasten cervical dilatation so that problems and hazards of prolonged labour both for the mother and fetus are minimised without increasing maternal or perinatal mortality and morbidity. AIMS AND OBJECTIVES To compare the effect of camylofin dihydrochloride with combination of valethemate bromide (epidosin) & hyoscine N butyl bromide (buscopan) on ce...

The polarographic or voltammetric behaviour of a selected group of tetra-alkyl ammonium halides and related compounds in liquid sulphur dioxide was investigated, using a stationary disk platinum indicating micro-electrode and a silver/silver-bromide reference electrode withcompensation for the IR drop of the solution. The electrochemical oxidation-reduction patterns are characteristic of the na...

This paper deals with development and validation of a high performance liquid chromatographic method for the quantitative determination of disodium EDTA (Ethylenediaminetetraacetic acid) in Meropenem active pharmaceutical ingredient (API). EDTA was derivatized with Ferric chloride solution by heating at 70 °C in water bath for about 20 minutes and the chromatographic separation achieved by inje...

Synthesis of a pentasil-type zeolite with ultra-small few-unit-cell crystalline domains, which we call FDP (few-unit-cell domain pentasil), is reported. made using bis-1,5(tributyl ammonium) pentamethylene cations as structure directing agent (SDA). This di-quaternary ammonium SDA combines butyl ammonium, in place the one commonly used for MFI synthesis, propyl and five-carbon nitrogen-connecti...