نتایج جستجو برای: buthionine sulfoximine
تعداد نتایج: 1267 فیلتر نتایج به سال:
Methylmercury (MeHg)-resistant sublines of rat pheochromocytoma (PC12) cells were isolated by repeated exposure to stepwise increased concentrations of MeHg. One of the sublines (PC12/TM) showed an 8- to 10-fold increase in resistance to MeHg compared with parent PC12 cells on the basis of the concentration required for 50% inhibition (IC50) of growth. PC12/TM cells accumulated smaller amounts ...
Behavioural Supports Ontario (BSO) was launched to enhance the healthcare services for Ontario's seniors, their caregivers and families living and coping with responsive behaviours associated with dementia and other neurological conditions. The implementation of the program varied across and within the local health integration networks (LHINs). By 2015, there were three BSO models operating wit...
We report an investigation on optical and scintillation properties and radiation hardness of four 20 cm long BSO crystals grown at SIC for the HHCAL detector concept. Their optical and scintillation properties, such as longitudinal transmittance, light output and light response uniformity, were measured before and after γ-ray irradiation. Progresses are observed in optical quality, light output...
Purpurin is a major anthraquinone present in the roots of Rubia cordifolia (madder). known to activate Nrf2 (Nuclear transcription factor erythroid 2-related 2) EpRE (electrophile responsive element) mediated gene expression as potential beneficial effect. This study aimed elucidate balance between electrophilicity or pro-oxidant activity purpurin underlying induction. For this, activation with...
Measles virus (MV) is a highly contagious agent which causes a major health problem in developing countries. We studied the effect of buthionine sulfoximine (BSO) on the replication of an AIK-HDC strain of MV and its induced apoptosis in Vero cell lines. Methods: In this study, toxicity of BSO on Vero cells was investigated first, resulted in determination of sub-lethal or non-toxic concentrati...
Selective inhibition of exclusively transcription-regulating PTEFb/CDK9 is a promising new approach in cancer therapy. Starting from lead compound BAY-958, lead optimization efforts strictly focusing on kinase selectivity, physicochemical and DMPK properties finally led to the identification of the orally available clinical candidate atuveciclib (BAY 1143572). Structurally characterized by an u...
In a direct two-level qubit system, when the Rabi frequency is comparable to the resonance frequency, the rotating wave approximation is not appropriate. In this case the Rabi oscillation is accompanied by another oscillation at twice the frequency of the driving field, the so called Bloch-Siegert oscillation (BSO), which depends on the initial phase of the field. This oscillation may restrict ...
Low-quality birds do not display high-quality signals: The cysteine-pheomelanin mechanism of honesty
The mechanisms that make that the costs of producing high-quality signals are unaffordable to low-quality signalers are a current issue in animal communication. The size of the melanin-based bib of male house sparrows Passer domesticus honestly signals quality. We induced the development of new bibs while treating males with buthionine-sulfoximine (BSO), a substance that depletes the levels of ...
The galaxy cluster RXJ 0152.7-1357 is emitting X-rays at the high rate of 148 counts ks −1. It would be one of the most luminous X-ray clusters known if it is at its redshift distance of z = .8325. It is conspicuously elongated, however, toward the bright, X-ray active galaxy NGC 720 about 14 arcmin away. At the same distance on the other side of NGC 720, and almost perfectly aligned, is an X-r...
The energy resolution of the hadronic calorimeters is mostly limited by the fluctuation of the electromagnetic component in the development of the shower. The dual readout technique proposed by DREAM aims to correct event by event for this fluctuation measuring at the same time scintillation and Cherenkov light. In the last years the DREAM Collaboration has performed several tests to exploit th...
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