Introduction. Volunteering in the field of medical activity, due to its high intensity, demand and irregular schedule, has a negative impact on mental health specialists contributes professional burnout. The study social attitudes interpersonal interaction volunteers context professionally oriented volunteer activities allows us identify not only their psychological readiness implement certain ...

Human oral squamous cell carcinomas (hSCCs) are the most common head and neck cancers now presenting with more aggressive biological clinical features due to smoking alcohol together widespread viremia. Transforming growth factor-β (TGF-β) proteins powerful morphogens that induce rapid substantial induction of endochondral bone formation but in primates only.

Sarcopenia is characterized by two major phenotypic components: low handgrip strength (HGS) and appendicular lean mass index (ASMI). Oral corticosteroid (OCS) use an important medication for acute respiratory exacerbations in patients with COPD asthma. However, the association of OCS sarcopenia components older people are largely unexplored. To examine between HGS or ASMI general population exp...

Background: The developmental competency of embryos is affected by several factors, including the developmental pathways and their elements. In mammalian species including goat, fertilized oocyte undergoes several divisions to form a structure called blastocyst. These events depend on the successful control of temporal and spatial expression of genes involved in genome activation. One of the cr...

during antigen capture and processing, mature dendritic cells (dc) express large amounts of peptide-mhc complexes and accessory molecules on their surface. we investigated the role of ifn-β in induction hla-g expression on the monocyte derived dc and cytokine profile in diabetes type 1. we accomplished secretary pattern and total cytokine production of the th1 cytokine (il-2, γifn) and th2 cyto...

amyloid-β (aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in alzheimer’s disease pathology.uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Oligomers of 40- or 42-mer amyloid β-protein (Aβ40, Aβ42) cause cognitive decline and synaptic dysfunction in Alzheimer's disease. We proposed the importance of a turn at Glu22 and Asp23 of Aβ42 to induce its neurotoxicity through the formation of radicals. Recently, a novel deletion mutant at Glu22 (E22Δ) of Aβ42 was reported to accelerate oligomerization and synaptotoxicity. To investigate th...